C₅H₂BrNOS

Base Information

• Chemical Name: C₅H₂BrNOS
• CAS No.: 1373346-87-2
• Molecular Formula: C₅H₂BrNOS
• Molecular Weight: 204.047
• Mol file: 1373346-87-2.mol

Synonyms:C₅H₂BrNOS

Chemical Property of C₅H₂BrNOS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of C₅H₂BrNOS

There total 1 articles about C₅H₂BrNOS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromothiophene-4-carboxylic acid (100523-84-0) → C5H2BrNOS (1373346-87-2)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In toluene; at 20 - 80 ℃; Inert atmosphere;

DOI:10.1021/ma902164q

Reference yield:

C5H2BrNOS (1373346-87-2) → 1-{5-[4-(α-D-mannopyranosyloxy)phenyl]thiophen-3-yl}urea (1373346-92-9)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonia / 1,4-dioxane / 0.5 h / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

3: sodium methylate / methanol / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; sodium methylate; caesium carbonate; In 1,4-dioxane; methanol; water; 2: Suzuki coupling;

DOI:10.1021/jm300165m

Reference yield:

C5H2BrNOS (1373346-87-2) + tert-butyl alcohol (75-65-0) → tert‐butyl N‐(5‐bromothiophen‐3‐yl)carbamate (494833-75-9)

Guidance literature:

In toluene; at 80 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ma902164q

upstream raw materials:

2-bromothiophene-4-carboxylic acid

Downstream raw materials:

tert‐butyl N‐(5‐bromothiophen‐3‐yl)carbamate

1-{5-[4-(α-D-mannopyranosyloxy)phenyl]thiophen-3-yl}urea