<5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>carbamic acid phenyl methyl ester

Base Information

• Chemical Name: <5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>carbamic acid phenyl methyl ester
• CAS No.: 103373-53-1
• Molecular Formula: C₂₃H₁₈FN₃O₂S
• Molecular Weight: 419.479

Synonyms:<5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>carbamic acid phenyl methyl ester

Chemical Property of <5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>carbamic acid phenyl methyl ester

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Technology Process of <5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>carbamic acid phenyl methyl ester

There total 2 articles about <5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>carbamic acid phenyl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(3RS)-3-benzyloxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one (103373-52-0) → <5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>carbamic acid phenyl methyl ester (103373-53-1)

Guidance literature:

With Lawessons reagent; In toluene; for 1.5h; Heating;

DOI:10.1021/jm00396a028

Reference yield:

2,4-bis-(4-methoxyphenyl)-2,4-dithioxo-1,3,2,4-dithiaphosphetane + (3RS)-3-benzyloxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one (103373-52-0) → <5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>carbamic acid phenyl methyl ester (103373-53-1)

Guidance literature:

In toluene;

Reference yield:

<5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>carbamic acid phenyl methyl ester (103373-53-1) → 1,3-dihydro-5-(2-fluorophenyl)-3-(RS)-amino-2H-1,4-benzodiazepin-2-thione (103373-59-7)

Guidance literature:

With hydrogen bromide; In dichloromethane; acetic acid; for 6h;

DOI:10.1021/jm00396a028

upstream raw materials:

(3RS)-3-benzyloxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one

Downstream raw materials:

1,3-dihydro-5-(2-fluorophenyl)-3-(RS)-amino-2H-1,4-benzodiazepin-2-thione

[5-(2-Fluoro-phenyl)-2-hydrazono-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester

1,3-Dihydro-5-(2-fluorophenyl)-3-(4-chlorophenyl)-carbonylamino-2H-1,4-benzodiazepin-2-thione

4-Chloro-N-[5-(2-fluoro-phenyl)-2-hydrazono-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-benzamide

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