3-phenyl-pentanedioic acid monomethyl ester

Base Information

• Chemical Name: 3-phenyl-pentanedioic acid monomethyl ester
• CAS No.: 132015-40-8
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.241
• Mol file: 132015-40-8.mol

Synonyms:3-phenyl-pentanedioic acid monomethyl ester

Chemical Property of 3-phenyl-pentanedioic acid monomethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-phenyl-pentanedioic acid monomethyl ester

There total 16 articles about 3-phenyl-pentanedioic acid monomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 3-phenylglutaric acid anhydride (4160-80-9) → 3-phenyl-pentanedioic acid monomethyl ester (132015-40-8)

Guidance literature:

for 144h; Heating;

DOI:10.1021/jm00107a041

Reference yield: 97.0%

methanol (67-56-1) + 3-phenylglutaric acid anhydride (4160-80-9) → 3-phenyl-pentanedioic acid monomethyl ester (95592-75-9,101713-10-4,132015-40-8,91478-85-2)

Guidance literature:

With N-((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide; In tert-butyl methyl ether; at -20 ℃; for 4h; optical yield given as %ee;

DOI:10.1002/anie.200801636

Reference yield: 97.0%

dimethyl 3-phenylpentanedioate (19006-47-4) → 3-phenyl-pentanedioic acid monomethyl ester (95592-75-9,101713-10-4,132015-40-8,91478-85-2)

Guidance literature:

With water; In 1,4-dioxane; at 5 ℃; pH=7; optical yield given as %ee; enantioselective reaction; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1016/j.tetasy.2011.11.012

upstream raw materials:

methanol

3-phenylglutaric acid anhydride

3-phenylglutaric acid

methyl iodide

Downstream raw materials:

(4R)-4-phenyltetrahydro-2H-pyran-2-one

(S)-3-Phenyl-pentanedioic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester methyl ester

dimethyl 3-phenylpentanedioate

(S)-4-phenyltetrahydro-2H-pyran-2-one

Refernces

• 1、 Nakajima, Ryota,Oono, Hiroyuki,Kumazawa, Keiko,Ida, Tomohide,Hirata, Jun,White, Ryan D.,Min, Xiaoshan,Guzman-Perez, Angel,Wang, Zhulun,Symons, Antony,Singh, Sanjay K.,Mothe, Srinivasa Reddy,Belyakov, Sergei,Chakrabarti, Anjan,Shuto, Satoshi. "Discovery of 6-Oxo-4-phenyl-hexanoic acid derivatives as RORγt inverse agonists showing favorable ADME profile". . . Retrieved 2021.
• 2、 Zhao, Jia-Jia,Yu, Shouyun. "Synthesis of chiral fluorides by sequential organocatalyzed desymmetrization of glutaric anhydrides and photoredox-catalyzed decarboxylic fluorination". supporting information. p. 391 - 394. Retrieved 2020/10/06.
• 3、 Fredes, Yerko,Chamorro, Lesly,Cabrera, Zaida. "Increased selectivity of novozym 435 in the asymmetric hydrolysis of a substrate with high hydrophobicity through the use of deep eutectic solvents and high substrate concentrations". . . Retrieved 2019/03/04.