N-{4-chloro-3-[(2-amino-5-chloro-4-(3,3-difluoropyrrolidin-1-yl)phenyl)thioureido]-benzyl}-2,2-dimethyl-propionamide

Base Information

Chemical Name:N-{4-chloro-3-[(2-amino-5-chloro-4-(3,3-difluoropyrrolidin-1-yl)phenyl)thioureido]-benzyl}-2,2-dimethyl-propionamide
CAS No.:1380920-99-9
Molecular Formula:C₂₃H₂₇Cl₂F₂N₅OS
Molecular Weight:530.469
Hs Code.:

Synonyms:N-{4-chloro-3-[(2-amino-5-chloro-4-(3,3-difluoropyrrolidin-1-yl)phenyl)thioureido]-benzyl}-2,2-dimethyl-propionamide

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Chemical Property of N-{4-chloro-3-[(2-amino-5-chloro-4-(3,3-difluoropyrrolidin-1-yl)phenyl)thioureido]-benzyl}-2,2-dimethyl-propionamide

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Technology Process of N-{4-chloro-3-[(2-amino-5-chloro-4-(3,3-difluoropyrrolidin-1-yl)phenyl)thioureido]-benzyl}-2,2-dimethyl-propionamide

There total 7 articles about N-{4-chloro-3-[(2-amino-5-chloro-4-(3,3-difluoropyrrolidin-1-yl)phenyl)thioureido]-benzyl}-2,2-dimethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1242269-88-0
N-(4-chloro-3-isothiocyanatobenzyl)-2,2-dimethyl-propionamide

: 4-chloro-5-(3,3-difluoropyrrolidin-1-yl)benzene-1,2-diamine dihydrochloride

: 1380920-99-9
N-{4-chloro-3-[(2-amino-5-chloro-4-(3,3-difluoropyrrolidin-1-yl)phenyl)thioureido]-benzyl}-2,2-dimethyl-propionamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1380920-99-9
N-{4-chloro-3-[(2-amino-5-chloro-4-(3,3-difluoropyrrolidin-1-yl)phenyl)thioureido]-benzyl}-2,2-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 1.5 h / 20 °C

2: hydrogen / Ra-Ni / tetrahydrofuran / 48 h / 20 °C / 2250.23 Torr

3: dichloromethane / 1.5 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

With hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; Ra-Ni; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 6641-64-1
4,5-dichloro-2-nitroaniline

: 1380920-99-9
N-{4-chloro-3-[(2-amino-5-chloro-4-(3,3-difluoropyrrolidin-1-yl)phenyl)thioureido]-benzyl}-2,2-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 130 °C

2: hydrogen / palladium on activated charcoal / tetrahydrofuran / 36 h / 20 °C / 22502.3 Torr

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;