tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate

Base Information

Chemical Name:tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate
CAS No.:1393901-35-3
Molecular Formula:C₂₁H₂₅ClF₃N₅O₂
Molecular Weight:471.91
Hs Code.:

Synonyms:tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate

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Chemical Property of tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate

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Technology Process of tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate

There total 3 articles about tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1393901-35-3
tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 150 °C / microwave irradiation

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; N,N-dimethyl-formamide; ethanol / 18 h / 20 °C / sealed tube

3.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.67 h / 0 °C

3.2: 18 h / 0 - 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; zinc(II) chloride; palladium 10% on activated carbon; In diethyl ether; ethanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1393901-35-3
tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 150 °C / microwave irradiation

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; N,N-dimethyl-formamide; ethanol / 18 h / 20 °C / sealed tube

3.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.67 h / 0 °C

3.2: 18 h / 0 - 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; zinc(II) chloride; palladium 10% on activated carbon; In diethyl ether; ethanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

: 392335-21-6
tert-butyl N-[1-(4-nitrophenyl)piperidin-4-yl]carbamate

: 1393901-35-3
tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidin-4-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; N,N-dimethyl-formamide; ethanol / 18 h / 20 °C / sealed tube

2.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.67 h / 0 °C

2.2: 18 h / 0 - 20 °C

With hydrogen; zinc(II) chloride; palladium 10% on activated carbon; In diethyl ether; ethanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;