(E)-3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-acrylic acid methyl ester

Base Information

Chemical Name:(E)-3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-acrylic acid methyl ester
CAS No.:1354060-42-6
Molecular Formula:C₂₂H₂₀Cl₂N₂O₃
Molecular Weight:431.318
Hs Code.:

Synonyms:(E)-3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-acrylic acid methyl ester

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Chemical Property of (E)-3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-acrylic acid methyl ester

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Technology Process of (E)-3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-acrylic acid methyl ester

There total 6 articles about (E)-3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5927-18-4
trimethyl phosphonoacetate

: 1354060-41-5
1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazole-3-carbaldehyde

: 1354060-42-6
(E)-3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-acrylic acid methyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In acetonitrile; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 635-93-8
5-chlorosalicyclaldehyde

: 1354060-42-6
(E)-3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.2: 17 h / 20 °C / Reflux

3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 100 °C

4.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

5.1: Dess-Martin periodane / dichloromethane / 3 h / 20 °C / Inert atmosphere

6.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 2 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; Dess-Martin periodane; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; potassium iodide; lithium chloride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 851205-62-4
1-(5-chloro-2-hydroxybenzyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1354060-42-6
(E)-3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 100 °C

2: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3: Dess-Martin periodane / dichloromethane / 3 h / 20 °C / Inert atmosphere

4: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 2 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide; lithium chloride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;