1,2-Diphenoxyethane

Base Information

• Chemical Name: 1,2-Diphenoxyethane
• CAS No.: 104-66-5
• Molecular Formula: C14H14O2
• Molecular Weight: 214.264
• Hs Code.: 29093090
• European Community (EC) Number: 203-224-9
• NSC Number: 6794
• UNII: V9W31HX4AW
• DSSTox Substance ID: DTXSID5026706
• Nikkaji Number: J5.033D
• Wikidata: Q3596743
• ChEMBL ID: CHEMBL1901367
• Mol file: 104-66-5.mol

Synonyms:1,2-diphenoxyethane

Chemical Property of 1,2-Diphenoxyethane

Chemical Property:

• Appearance/Colour: Off-white crystals
• Vapor Pressure: 0.000158mmHg at 25°C
• Melting Point: 94-96 °C(lit.)
• Refractive Index: 1.556
• Boiling Point: 341.555 °C at 760 mmHg
• Flash Point: 139.355 °C
• PSA: 18.46000
• Density: 1.08 g/cm³
• LogP: 3.14440
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• Water Solubility.: 22mg/L at 25℃
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 214.099379685
• Heavy Atom Count: 16
• Complexity: 150

Purity/Quality:

98%, ^*data from raw suppliers

1,2-Diphenoxyethane ^*data from reagent suppliers

Safty Information:

• Statements: 51/53
• Safety Statements: 22-24/25-61-36-29/56

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Other Aromatic Compounds
• Canonical SMILES: C1=CC=C(C=C1)OCCOC2=CC=CC=C2
• Uses: 1,2-Diphenoxyethane is a reagent that is used in the production and use of activatable delivery compounds containing drugs or a detectable moiety and singlet oxygen-labile linkers.

Technology Process of 1,2-Diphenoxyethane

There total 35 articles about 1,2-Diphenoxyethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(4-bromophenoxy)-2-phenoxyethane (30752-35-3) → 1,2-diphenoxyethane (104-66-5)

Guidance literature:

1-(4-bromophenoxy)-2-phenoxyethane; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

With hydrogenchloride; In tetrahydrofuran; Further stages.;

DOI:10.1021/ol070841b

Reference yield: 94.0%

iodobenzene (591-50-4) + ethylene glycol (107-21-1) → 1,2-diphenoxyethane (104-66-5)

Guidance literature:

With [2,2]bipyridinyl; copper(l) iodide; sodium carbonate; In N,N-dimethyl-formamide; at 100 ℃;

Reference yield: 91.0%

bromobenzene (108-86-1,52753-63-6) + ethylene glycol (107-21-1) → 1,2-diphenoxyethane (104-66-5)

Guidance literature:

With [2,2]bipyridinyl; copper(l) iodide; sodium carbonate; In N,N-dimethyl-formamide; at 100 ℃; Reagent/catalyst;

upstream raw materials:

potassium phenolate

sodium phenoxide

1,2-dichloro-ethane

ethanol

Downstream raw materials:

4,4'-(ethylenedioxy)dibromobenzene

1,2-bis(4-nitrophenoxy)ethane

4,4'-ethanediyldioxy-bis-benzenesulfonic acid bis-dimethylamide

4,4'-ethanediyldioxy-bis-benzenesulfonyl chloride

Refernces

• 1、 Miyake. "". . p. 3040,3041, 3042. Retrieved 1960.
• 2、 Tobias. "". . p. 4305. Retrieved 1968.
• 3、 Cope. "-". . p. 572. Retrieved 1935.
• 4、 -. "Thermo-sensitive paper sensitizer ethylene glycol diphenyl ether preparation method". Paragraph 0018-0027. . Retrieved 2019/08/03.