4-[2-(4-Formylphenoxy)ethoxy]benzaldehyde

Base Information

• Chemical Name: 4-[2-(4-Formylphenoxy)ethoxy]benzaldehyde
• CAS No.: 34074-28-7
• Molecular Formula: C16H14 O4
• Molecular Weight: 270.285
• Hs Code.: 2912299000
• DSSTox Substance ID: DTXSID901248555
• Nikkaji Number: J1.244.098G
• ChEMBL ID: CHEMBL2380560
• Mol file: 34074-28-7.mol

Synonyms:4-[2-(4-Formylphenoxy)ethoxy]benzaldehyde;34074-28-7;1,2-Bis(4-formylphenoxy)ethane;SCHEMBL851166;CHEMBL2380560;4,4'-Ethylenedioxybisbenzaldehyde;DTXSID901248555;4,4'-(ethylenedioxy)dibenzaldehyde;MFCD00021075;4-[2-(4-Formylphenoxy)ethoxy]benzaldehyde #;4,4'-[1,2-Ethanediylbis(oxy)]bis-benzaldehyde;4,4'-[1,2-Ethanediylbis(oxy)]bis[benzaldehyde];Benzaldehyde, 4,4'-[1,2-ethanediylbis(oxy)]bis-

Chemical Property of 4-[2-(4-Formylphenoxy)ethoxy]benzaldehyde

Chemical Property:

• PSA: 52.60000
• LogP: 2.76940
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 270.08920892
• Heavy Atom Count: 20
• Complexity: 259

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C=O)OCCOC2=CC=C(C=C2)C=O

Technology Process of 4-[2-(4-Formylphenoxy)ethoxy]benzaldehyde

There total 15 articles about 4-[2-(4-Formylphenoxy)ethoxy]benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

ethylene glycol bis[4-(ethoxycarbonyl)phenyl] ether (25909-66-4) → 1,2-bis(4-formylphenoxy)ethane (34074-28-7)

Guidance literature:

With 1-methyl-piperazine; sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at 25 ℃; for 3h;

Reference yield: 92.0%

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) + ethylene dibromide (106-93-4) → 1,2-bis(4-formylphenoxy)ethane (34074-28-7)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 20h; Reflux; Inert atmosphere;

DOI:10.1039/c5nj00582e

Reference yield: 83.3%

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 1,2-bis(4-formylphenoxy)ethane (34074-28-7)

Guidance literature:

With potassium carbonate; In acetonitrile; Reflux;

DOI:10.1016/j.bmcl.2017.03.060

upstream raw materials:

hydrogen cyanide

1,2-diphenoxyethane

4-hydroxy-benzaldehyde

ethylene dibromide

Downstream raw materials:

1,2-bis-(4-phenethylaminomethyl-phenoxy)-ethane

4,4'-ethanediyldioxy-di-benzaldehyde bis-(1-methyl-hexylimine)

2,2'-dicyano-3,3'-(4,4'-ethylenedioxydiphenyl)bis(thioacrylamide)

C₂₂H₂₀N₂O₆

Refernces

• 1、 Borges, Márcia Narcizo,Messeder, Jorge Cardoso,Figueroa-Villar, José Daniel. "Synthesis, anti-Trypanosoma cruzi activity and micelle interaction studies of bisguanylhydrazones analogous to pentamidine". . p. 925 - 929. Retrieved 2004.
• 2、 Darweesh, Ahmed F.,Salama, Soad K.,Abdelhamid, Ismail A.,Elwahy, Ahmed H. M.. "Green synthesis of novel bis(hexahydro-1H-xanthene-1,8(2H)-diones) employing p-toluenesulfonic acid (p-TSA) as a solid acid catalyst". . p. 471 - 484. Retrieved 2021.
• 3、 Hirsch, Anna K. H.,Imberty, Anne,Kinsinger, Thorsten,Kuhaudomlarp, Sakonwan,Lepsik, Martin,Minervini, Saverio,Titz, Alexander,Yousaf, Sultaan,Zahorska, Eva. "A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d-galactose pentaacetate". . p. 8822 - 8825. Retrieved 2020.
• 4、 Ghamari Kargar, Pouya,Bagherzade, Ghodsieh,Eshghi, Hossein. "Introduction of a trinuclear manganese(iii) catalyst on the surface of magnetic cellulose as an eco-benign, efficient and reusable novel heterogeneous catalyst for the multi-component synthesis of new derivatives of xanthene". . p. 4339 - 4355. Retrieved 2021/02/03.