(S)-6-(tert-Butyl-dimethyl-silanyloxy)-1-((R)-1-hydroxymethyl-2-phenyl-ethylamino)-hexan-2-ol

Base Information

Chemical Name:(S)-6-(tert-Butyl-dimethyl-silanyloxy)-1-((R)-1-hydroxymethyl-2-phenyl-ethylamino)-hexan-2-ol
CAS No.:680974-91-8
Molecular Formula:C₂₁H₃₉NO₃Si
Molecular Weight:381.631
Hs Code.:

Synonyms:(S)-6-(tert-Butyl-dimethyl-silanyloxy)-1-((R)-1-hydroxymethyl-2-phenyl-ethylamino)-hexan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-6-(tert-Butyl-dimethyl-silanyloxy)-1-((R)-1-hydroxymethyl-2-phenyl-ethylamino)-hexan-2-ol

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Technology Process of (S)-6-(tert-Butyl-dimethyl-silanyloxy)-1-((R)-1-hydroxymethyl-2-phenyl-ethylamino)-hexan-2-ol

There total 1 articles about (S)-6-(tert-Butyl-dimethyl-silanyloxy)-1-((R)-1-hydroxymethyl-2-phenyl-ethylamino)-hexan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 5267-64-1
(R)-2-amino-3-phenylpropanol

: 429687-44-5
(S)-2-[4-(tert-butyldimethylsilyloxy)-1-butyl]oxirane

: 680974-91-8
(S)-6-(tert-Butyl-dimethyl-silanyloxy)-1-((R)-1-hydroxymethyl-2-phenyl-ethylamino)-hexan-2-ol

Guidance literature:: In propan-1-ol; for 17h; Heating;
DOI:10.1021/ol049861t

Reference yield: 96.0%

: 75-77-4
chloro-trimethyl-silane

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 680974-91-8
(S)-6-(tert-Butyl-dimethyl-silanyloxy)-1-((R)-1-hydroxymethyl-2-phenyl-ethylamino)-hexan-2-ol

: 680974-92-9
[(S)-6-(tert-Butyl-dimethyl-silanyloxy)-2-trimethylsilanyloxy-hexyl]-((R)-2-phenyl-1-trimethylsilanyloxymethyl-ethyl)-amine

Guidance literature:: In tetrahydrofuran; at 0 - 23 ℃;
DOI:10.1021/ol049861t

Reference yield:

: 680974-91-8
(S)-6-(tert-Butyl-dimethyl-silanyloxy)-1-((R)-1-hydroxymethyl-2-phenyl-ethylamino)-hexan-2-ol

: (2S,5R)-2-[4-(tert-butyldimethylsilyloxy)-1-butyl]-5-benzylmorpholine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 96 percent / tetrahydrofuran / 0 - 23 °C

2.1: 93 percent / Et₃N; pyridine / 1.33 h / 23 °C

3.1: 95 percent / MeONa; MeOH / 0.67 h / 23 °C

4.1: Et₃N; DMAP / CH₂Cl₂ / 3.2 h / 23 °C

5.1: Et₃N; DMAP; TsCl / CH₂Cl₂ / 3.2 h / 23 °C

5.2: 80 percent / K₂CO₃ / 2-methyl-propan-2-ol / 28.5 h / 83 °C / Heating

6.1: 66 percent / NaC₁₀H₈ / tetrahydrofuran / 0.08 h / -78 °C

With pyridine; methanol; dmap; NaC₁₀H₈; sodium methylate; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol049861t