3-(2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazolin]-3'-yl)phenol

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Chemical Name:3-(2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazolin]-3'-yl)phenol
CAS No.:1184103-34-1
Molecular Formula:C₂₅H₂₅N₅O
Molecular Weight:411.506
Hs Code.:

Synonyms:3-(2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazolin]-3'-yl)phenol

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Chemical Property of 3-(2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazolin]-3'-yl)phenol

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Technology Process of 3-(2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazolin]-3'-yl)phenol

There total 6 articles about 3-(2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazolin]-3'-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1184103-29-4
3'-(3-methoxyphenyl)-2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazoline]

: 1184103-34-1
3-(2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazolin]-3'-yl)phenol

Guidance literature:: 3'-(3-methoxyphenyl)-2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazoline]; With boron tribromide; In dichloromethane; for 2h;

With sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 6457-49-4
4-piperidinemethanol

: 1184103-34-1
3-(2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazolin]-3'-yl)phenol

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: Dess-Martin periodane / dichloromethane / 0 °C

3: ethanol; potassium hydroxide / 70 °C

4: hydrogen / palladium on activated charcoal / ethyl acetate / 3 h

5: 9 h / 110 °C

6: acetic acid / ethanol / 4.5 h / 80 °C

7: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

8: boron tribromide / dichloromethane / 2 h

With ethanol; hydrogen; boron tribromide; Dess-Martin periodane; acetic acid; triethylamine; trifluoroacetic acid; potassium hydroxide; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate;

Reference yield:

: 873924-07-3
9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylic acid tert-butyl ester

: 1184103-34-1
3-(2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazolin]-3'-yl)phenol

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium on activated charcoal / ethyl acetate / 3 h

2: 9 h / 110 °C

3: acetic acid / ethanol / 4.5 h / 80 °C

4: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

5: boron tribromide / dichloromethane / 2 h

With hydrogen; boron tribromide; acetic acid; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate;