3'-(3-methoxyphenyl)-2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazoline]

Base Information

Chemical Name:3'-(3-methoxyphenyl)-2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazoline]
CAS No.:1184103-29-4
Molecular Formula:C₂₆H₂₇N₅O
Molecular Weight:425.533
Hs Code.:

Synonyms:3'-(3-methoxyphenyl)-2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazoline]

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Chemical Property of 3'-(3-methoxyphenyl)-2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazoline]

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Technology Process of 3'-(3-methoxyphenyl)-2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazoline]

There total 5 articles about 3'-(3-methoxyphenyl)-2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazoline] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1184103-24-9
tert-butyl 3'-(3-methoxyphenyl)-2'-pyridin-4-yl-8',9'-dihydro-1H,6'H-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazoline]-1-carboxylate

: 1184103-29-4
3'-(3-methoxyphenyl)-2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazoline]

Guidance literature:: tert-butyl 3'-(3-methoxyphenyl)-2'-pyridin-4-yl-8',9'-dihydro-1H,6'H-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazoline]-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

With sodium carbonate; In dichloromethane;

Reference yield:

: 6457-49-4
4-piperidinemethanol

: 1184103-29-4
3'-(3-methoxyphenyl)-2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazoline]

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: Dess-Martin periodane / dichloromethane / 0 °C

3: ethanol; potassium hydroxide / 70 °C

4: hydrogen / palladium on activated charcoal / ethyl acetate / 3 h

5: 9 h / 110 °C

6: acetic acid / ethanol / 4.5 h / 80 °C

7: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

With ethanol; hydrogen; Dess-Martin periodane; acetic acid; triethylamine; trifluoroacetic acid; potassium hydroxide; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate;

Reference yield:

: 873924-07-3
9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylic acid tert-butyl ester

: 1184103-29-4
3'-(3-methoxyphenyl)-2'-pyridin-4-yl-8',9'-dihydro-6'h-spiro[piperidine-4,7'-pyrazolo[1,5-a]quinazoline]

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium on activated charcoal / ethyl acetate / 3 h

2: 9 h / 110 °C

3: acetic acid / ethanol / 4.5 h / 80 °C

4: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

With hydrogen; acetic acid; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate;