3-(2-methylthiopyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-6-(N-carbobenzoxypiperidin-4-yl)peridazine

Base Information

Chemical Name:3-(2-methylthiopyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-6-(N-carbobenzoxypiperidin-4-yl)peridazine
CAS No.:271247-47-3
Molecular Formula:C₂₉H₂₆F₃N₅O₂S
Molecular Weight:565.619
Hs Code.:

Synonyms:3-(2-methylthiopyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-6-(N-carbobenzoxypiperidin-4-yl)peridazine

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Chemical Property of 3-(2-methylthiopyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-6-(N-carbobenzoxypiperidin-4-yl)peridazine

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Technology Process of 3-(2-methylthiopyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-6-(N-carbobenzoxypiperidin-4-yl)peridazine

There total 5 articles about 3-(2-methylthiopyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-6-(N-carbobenzoxypiperidin-4-yl)peridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 443958-81-4
1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)-4-oxo-4-(N-carbobenzoxypiperidin-4-yl)butane

: 271247-47-3
3-(2-methylthiopyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-6-(N-carbobenzoxypiperidin-4-yl)peridazine

Guidance literature:: Multi-step reaction with 2 steps

1: N₂H₄ / ethanol / 5 h / 20 °C

2: DDQ / toluene / 0.5 h / 20 °C

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; hydrazine; In ethanol; toluene;
DOI:10.1016/S0960-894X(01)00834-4

Reference yield:

: 4-[6-(2-methylsulfanyl-pyrimidin-4-yl)-5-(3-trifluoromethyl-phenyl)-4,5-dihydro-pyridazin-3-yl]-piperidine-1-carboxylic acid benzyl ester

: 271247-47-3
3-(2-methylthiopyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-6-(N-carbobenzoxypiperidin-4-yl)peridazine

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In toluene; at 20 ℃; for 0.5h;
DOI:10.1016/S0960-894X(01)00834-4

Reference yield:

: 705-29-3
3-Trifluoromethylbenzyl chloride

: 271247-47-3
3-(2-methylthiopyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-6-(N-carbobenzoxypiperidin-4-yl)peridazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: Mg; I₂ / diethyl ether / 0.5 h / Heating

1.2: 15 percent / diethyl ether / 4 h / Heating

2.1: NaH / dimethylsulfoxide / 0.25 h / 20 °C

2.2: 21 percent / dimethylsulfoxide / 18 h / 20 °C

3.1: N₂H₄ / ethanol / 5 h / 20 °C

4.1: DDQ / toluene / 0.5 h / 20 °C

With iodine; sodium hydride; magnesium; 2,3-dicyano-5,6-dichloro-p-benzoquinone; hydrazine; In diethyl ether; ethanol; dimethyl sulfoxide; toluene;
DOI:10.1016/S0960-894X(01)00834-4