1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)-4-oxo-4-(N-carbobenzoxypiperidin-4-yl)butane

Base Information

• Chemical Name: 1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)-4-oxo-4-(N-carbobenzoxypiperidin-4-yl)butane
• CAS No.: 443958-81-4
• Molecular Formula: C₂₉H₂₈F₃N₃O₄S
• Molecular Weight: 571.62
• Mol file: 443958-81-4.mol

Synonyms:1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)-4-oxo-4-(N-carbobenzoxypiperidin-4-yl)butane

Chemical Property of 1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)-4-oxo-4-(N-carbobenzoxypiperidin-4-yl)butane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)-4-oxo-4-(N-carbobenzoxypiperidin-4-yl)butane

There total 3 articles about 1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)-4-oxo-4-(N-carbobenzoxypiperidin-4-yl)butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

4-(2-chloroacetyl)piperidine-1-carboxylic acid benzyl ester (85475-10-1) + 1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)ethane (271247-45-1) → 1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)-4-oxo-4-(N-carbobenzoxypiperidin-4-yl)butane (443958-81-4)

Guidance literature:

1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)ethane; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 0.25h;

4-(2-chloroacetyl)piperidine-1-carboxylic acid benzyl ester; In dimethyl sulfoxide; at 20 ℃; for 18h;

DOI:10.1016/S0960-894X(01)00834-4

Reference yield:

3-Trifluoromethylbenzyl chloride (705-29-3) → 1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)-4-oxo-4-(N-carbobenzoxypiperidin-4-yl)butane (443958-81-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Mg; I₂ / diethyl ether / 0.5 h / Heating

1.2: 15 percent / diethyl ether / 4 h / Heating

2.1: NaH / dimethylsulfoxide / 0.25 h / 20 °C

2.2: 21 percent / dimethylsulfoxide / 18 h / 20 °C

With iodine; sodium hydride; magnesium; In diethyl ether; dimethyl sulfoxide;

DOI:10.1016/S0960-894X(01)00834-4

Reference yield:

2-methylsulfanyl-pyrimidine-4-carboxylic acid methoxy-methyl-amide (271247-59-7) → 1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)-4-oxo-4-(N-carbobenzoxypiperidin-4-yl)butane (443958-81-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Mg; I₂ / diethyl ether / 0.5 h / Heating

1.2: 15 percent / diethyl ether / 4 h / Heating

2.1: NaH / dimethylsulfoxide / 0.25 h / 20 °C

2.2: 21 percent / dimethylsulfoxide / 18 h / 20 °C

With iodine; sodium hydride; magnesium; In diethyl ether; dimethyl sulfoxide;

DOI:10.1016/S0960-894X(01)00834-4

upstream raw materials:

4-(2-chloroacetyl)piperidine-1-carboxylic acid benzyl ester

1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)ethane

3-Trifluoromethylbenzyl chloride

2-methylsulfanyl-pyrimidine-4-carboxylic acid methoxy-methyl-amide

Downstream raw materials:

(S)-3-[2-(α-methylbenzylamino)pyrimidin-4-yl]-4-(3-trifluoromethylphenyl)-6-(N-carbobenzoxypiperidin-4-yl)pyridazine

3-(2-methylsulfonylpyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-6-(N-carbobenzoxypiperidin-4-yl)pyridazine

3-(2-methylthiopyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-6-(N-carbobenzoxypiperidin-4-yl)peridazine