1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)ethane

Base Information

Chemical Name:1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)ethane
CAS No.:271247-45-1
Molecular Formula:C₁₄H₁₁F₃N₂OS
Molecular Weight:312.315
Hs Code.:

Synonyms:1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)ethane

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Chemical Property of 1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)ethane

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Technology Process of 1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)ethane

There total 1 articles about 1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 705-29-3
3-Trifluoromethylbenzyl chloride

: 271247-59-7
2-methylsulfanyl-pyrimidine-4-carboxylic acid methoxy-methyl-amide

: 271247-45-1
1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)ethane

Guidance literature:: 3-Trifluoromethylbenzyl chloride; With iodine; magnesium; In diethyl ether; for 0.5h; Heating;

2-methylsulfanyl-pyrimidine-4-carboxylic acid methoxy-methyl-amide; In diethyl ether; for 4h; Heating;
DOI:10.1016/S0960-894X(01)00834-4

Reference yield: 21.0%

: 85475-10-1
4-(2-chloroacetyl)piperidine-1-carboxylic acid benzyl ester

: 271247-45-1
1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)ethane

: 443958-81-4
1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)-4-oxo-4-(N-carbobenzoxypiperidin-4-yl)butane

Guidance literature:: 1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)ethane; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 0.25h;

4-(2-chloroacetyl)piperidine-1-carboxylic acid benzyl ester; In dimethyl sulfoxide; at 20 ℃; for 18h;
DOI:10.1016/S0960-894X(01)00834-4

Reference yield:

: 271247-45-1
1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)ethane

: (S)-3-[2-(α-methylbenzylamino)pyrimidin-4-yl]-4-(3-trifluoromethylphenyl)-6-(piperidin-4-yl)pyridazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / dimethylsulfoxide / 0.25 h / 20 °C

1.2: 21 percent / dimethylsulfoxide / 18 h / 20 °C

2.1: N₂H₄ / ethanol / 5 h / 20 °C

3.1: DDQ / toluene / 0.5 h / 20 °C

4.1: 49 percent / 30 percent H₂O₂; Na₂WO₄*2H₂O / methanol; ethyl acetate / 18 h / Heating

5.1: 94 percent / 3 h / 125 °C

6.1: 30 percent / HBr; HOAc / 1 h / 20 °C

With sodium tungstate; hydrogen bromide; dihydrogen peroxide; sodium hydride; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; hydrazine; In methanol; ethanol; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1016/S0960-894X(01)00834-4