N-Methoxy-N-Methyl-2-(Methylthio)pyriMidine-4-carboxaMide

Base Information

• Chemical Name: N-Methoxy-N-Methyl-2-(Methylthio)pyriMidine-4-carboxaMide
• CAS No.: 271247-59-7
• Molecular Formula: C8H11N3O2S
• Molecular Weight: 213.26
• Mol file: 271247-59-7.mol

Synonyms:2-methylsulfanyl-pyrimidine-4-carboxylic acid methoxy-methyl-amide;4-Pyrimidinecarboxamide,N-methoxy-N-methyl-2-(methylthio);

Chemical Property of N-Methoxy-N-Methyl-2-(Methylthio)pyriMidine-4-carboxaMide

Chemical Property:

• PSA: 80.62000
• LogP: 0.83190

Purity/Quality:

more than 97% ^*data from raw suppliers

N-Methoxy-N-methyl-2-(methylthio)pyrimidine-4-carboxamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Methoxy-N-Methyl-2-(Methylthio)pyriMidine-4-carboxaMide

There total 2 articles about N-Methoxy-N-Methyl-2-(Methylthio)pyriMidine-4-carboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-methylsulfanylpyrimidine-4-carboxylic acid (1126-44-9) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 2-methylsulfanyl-pyrimidine-4-carboxylic acid methoxy-methyl-amide (271247-59-7)

Guidance literature:

2-methylsulfanylpyrimidine-4-carboxylic acid; N,O-dimethylhydroxylamine*hydrochloride; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In acetonitrile; at 20 ℃; for 16h;

With sodium hydrogencarbonate; In water; acetonitrile;

Reference yield: 88.0%

2-methylsulfanylpyrimidine-4-carboxylic acid (1126-44-9) + N,0-dimethylhydroxylamine (1117-97-1) → 2-methylsulfanyl-pyrimidine-4-carboxylic acid methoxy-methyl-amide (271247-59-7)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 15.0%

3-Trifluoromethylbenzyl chloride (705-29-3) + 2-methylsulfanyl-pyrimidine-4-carboxylic acid methoxy-methyl-amide (271247-59-7) → 1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)ethane (271247-45-1)

Guidance literature:

3-Trifluoromethylbenzyl chloride; With iodine; magnesium; In diethyl ether; for 0.5h; Heating;

2-methylsulfanyl-pyrimidine-4-carboxylic acid methoxy-methyl-amide; In diethyl ether; for 4h; Heating;

DOI:10.1016/S0960-894X(01)00834-4

upstream raw materials:

2-methylsulfanylpyrimidine-4-carboxylic acid

N,O-dimethylhydroxylamine*hydrochloride

N,0-dimethylhydroxylamine

Downstream raw materials:

1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)ethane

1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)-4-oxo-4-(N-carbobenzoxypiperidin-4-yl)butane

3-(2-methylthiopyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-6-(N-carbobenzoxypiperidin-4-yl)peridazine

3-(2-methylsulfonylpyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-6-(N-carbobenzoxypiperidin-4-yl)pyridazine