[1-(methoxy-methyl-carbamoyl)-2-phenyl-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: [1-(methoxy-methyl-carbamoyl)-2-phenyl-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester
• CAS No.: 227624-29-5
• Molecular Formula: C₂₆H₂₆N₂O₄
• Molecular Weight: 430.503
• Mol file: 227624-29-5.mol

Synonyms:[1-(methoxy-methyl-carbamoyl)-2-phenyl-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Chemical Property of [1-(methoxy-methyl-carbamoyl)-2-phenyl-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-(methoxy-methyl-carbamoyl)-2-phenyl-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 4 articles about [1-(methoxy-methyl-carbamoyl)-2-phenyl-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + Fmoc-D-Phe-OH (86123-10-6) → [1-(methoxy-methyl-carbamoyl)-2-phenyl-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester (227624-29-5)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane; at 20 ℃; for 2h; pH=8;

DOI:10.1016/S0040-4020(03)00583-0

Reference yield:

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + Fmoc-D-phenylalanine acid chloride (103321-58-0) → [1-(methoxy-methyl-carbamoyl)-2-phenyl-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester (227624-29-5)

Guidance literature:

In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1080/00397911.2018.1531295

Reference yield:

Fmoc-D-Phe-OH (86123-10-6) + N,0-dimethylhydroxylamine (1117-97-1) → [1-(methoxy-methyl-carbamoyl)-2-phenyl-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester (227624-29-5)

Guidance literature:

Fmoc-D-Phe-OH; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N,0-dimethylhydroxylamine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1021/jm101425m

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

Fmoc-D-Phe-OH

N,0-dimethylhydroxylamine

Fmoc-D-phenylalanine acid chloride

Downstream raw materials:

(-)-(R)-(N-9-fluorenylmethoxycarbonyl)phenylalaninal