(S)-3-amino-9-chloro-5-(3-cyclopropylphenyl)-4,5-dihydro-1H-benzo-[b][1,4]-diazepin-2(3H)-one

Base Information

Chemical Name:(S)-3-amino-9-chloro-5-(3-cyclopropylphenyl)-4,5-dihydro-1H-benzo-[b][1,4]-diazepin-2(3H)-one
CAS No.:1584150-20-8
Molecular Formula:C₁₈H₁₈ClN₃O
Molecular Weight:327.813
Hs Code.:

Synonyms:(S)-3-amino-9-chloro-5-(3-cyclopropylphenyl)-4,5-dihydro-1H-benzo-[b][1,4]-diazepin-2(3H)-one

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Chemical Property of (S)-3-amino-9-chloro-5-(3-cyclopropylphenyl)-4,5-dihydro-1H-benzo-[b][1,4]-diazepin-2(3H)-one

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Technology Process of (S)-3-amino-9-chloro-5-(3-cyclopropylphenyl)-4,5-dihydro-1H-benzo-[b][1,4]-diazepin-2(3H)-one

There total 5 articles about (S)-3-amino-9-chloro-5-(3-cyclopropylphenyl)-4,5-dihydro-1H-benzo-[b][1,4]-diazepin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1584150-21-9
(S)-tert-butyl (6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamate

: 1584150-20-8
(S)-3-amino-9-chloro-5-(3-cyclopropylphenyl)-4,5-dihydro-1H-benzo-[b][1,4]-diazepin-2(3H)-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2h;

Reference yield:

: 64182-61-2
1-chloro-3-fluoro-2-nitrobenzene

: 1584150-20-8
(S)-3-amino-9-chloro-5-(3-cyclopropylphenyl)-4,5-dihydro-1H-benzo-[b][1,4]-diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / ethanol / 9 h / 80 °C / Inert atmosphere

2: ammonium chloride; ethanol; iron / water / 1.5 h / 80 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 3 h

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; potassium carbonate / tert-butyl alcohol / 80 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 2 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ethanol; iron; potassium carbonate; ammonium chloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; XPhos; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1584150-10-6
(S)-tert-butyl (9-chloro-2-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamate

: 1584150-20-8
(S)-3-amino-9-chloro-5-(3-cyclopropylphenyl)-4,5-dihydro-1H-benzo-[b][1,4]-diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; potassium carbonate / tert-butyl alcohol / 80 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; trifluoroacetic acid; XPhos; In dichloromethane; tert-butyl alcohol;