Technology Process of Z-Ala-Gly-Cys(MBzl)-Lys(Z)-Asn-Phe-Phe-NHNH2
There total 12 articles about Z-Ala-Gly-Cys(MBzl)-Lys(Z)-Asn-Phe-Phe-NHNH2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
at 0 ℃;
for 0.25h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: DCC / ethyl acetate / 2.17 h / 0 °C
2: sodium hydrogen carbonate / H2O; tetrahydrofuran / 0.08 h
3: DCC / ethyl acetate / 4 h / 0 °C
4: triethylamine / ethyl acetate / 0.08 h
5: 87.5 percent / hydrazyne hydrate / methanol / 48 h / Ambient temperature
6: 1) 2.2N hydrogen chloride, tert-butyl nitrite 2) triethylamine / 1) -30deg C, DMF, 20 min 2) 0 deg C, DMF, 2 days
7: 85 percent / 90percent trifluoroacetic acid / 0.25 h / 0 °C
With
hydrogenchloride; tert.-butylnitrite; sodium hydrogencarbonate; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
tetrahydrofuran; methanol; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: DCC / ethyl acetate / 0 °C
2: 80 percent / CHCl3 / 0.17 h
3: hydrogen / methanol / 3 h
4: tetrahydrofuran / 0.5 h
5: hydrogen / dimethylformamide / 1 h / Ambient temperature
6: 1) 2.2N hydrogen chloride, tert-butyl nitrite 2) triethylamine / 1) -30deg C, DMF, 20 min 2) 0 deg C, DMF, 2 days
7: 85 percent / 90percent trifluoroacetic acid / 0.25 h / 0 °C
With
hydrogenchloride; tert.-butylnitrite; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
tetrahydrofuran; methanol; chloroform; ethyl acetate; N,N-dimethyl-formamide;
