2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl-(2,6-dichloro-3-fluorophenyl)methanol

Base Information

Chemical Name:2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl-(2,6-dichloro-3-fluorophenyl)methanol
CAS No.:1349722-69-5
Molecular Formula:C₁₃H₇BrCl₂FN₃O
Molecular Weight:391.026
Hs Code.:

Synonyms:2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl-(2,6-dichloro-3-fluorophenyl)methanol

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Chemical Property of 2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl-(2,6-dichloro-3-fluorophenyl)methanol

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Technology Process of 2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl-(2,6-dichloro-3-fluorophenyl)methanol

There total 5 articles about 2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl-(2,6-dichloro-3-fluorophenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 178813-77-9
2,6-dichloro-3-fluorobenzaldehyde

: 875781-43-4
2-bromo-5H-pyrrolo[2,3-b]pyrazine

: 1349722-69-5
2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl-(2,6-dichloro-3-fluorophenyl)methanol

: 1349722-64-0
2-bromo-7-[(2,6-dichloro-3-fluorophenyl)(methoxy)methyl]-5H-pyrrolo[2,3-b]pyrazine

Guidance literature:: With potassium hydroxide; at 20 ℃; for 16h;

Reference yield:

: 1435-48-9
1,3-dichloro-4-fluorobenzene

: 1349722-69-5
2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl-(2,6-dichloro-3-fluorophenyl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: potassium hydroxide / 16 h / 20 °C

With n-butyllithium; potassium hydroxide; In tetrahydrofuran; hexane;

Reference yield:

: 178813-78-0
2,6?dichloro?3?fluorobenzoic acid

: 1349722-69-5
2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl-(2,6-dichloro-3-fluorophenyl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: borane-THF / tetrahydrofuran / 12 h / Reflux

2: sodium hydrogencarbonate; sodium hypochlorite; sodium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water / 1.5 h / -2 °C

3: potassium hydroxide / 16 h / 20 °C

With sodium hypochlorite; borane-THF; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide; potassium hydroxide; In tetrahydrofuran; water;