4-(5-chloro-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide

Base Information

Chemical Name:4-(5-chloro-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide
CAS No.:1552281-02-3
Molecular Formula:C₂₄H₁₉ClFN₅O₄
Molecular Weight:495.897
Hs Code.:

Synonyms:4-(5-chloro-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide

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Chemical Property of 4-(5-chloro-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide

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Technology Process of 4-(5-chloro-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide

There total 6 articles about 4-(5-chloro-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.5%

: 99586-65-9
4-chloropicolinamide

: N-(2-chloro-5-fluoro-4-hydroxyphenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

: 1552281-02-3
4-(5-chloro-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 120 ℃; for 15h;

Reference yield:

: 771-76-6
2-chloro-4,5-difluoronitrobenzene

: 1552281-02-3
4-(5-chloro-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide / water / 3 h / Reflux

2: iron; ammonium chloride / water; ethanol / 10 h / 20 °C

3: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 80 °C

4: potassium tert-butylate / N,N-dimethyl-formamide / 15 h / 120 °C

With 1-hydroxy-7-aza-benzotriazole; potassium tert-butylate; iron; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 696-02-6
4-chloro-1,2-difluorobenzene

: 1552281-02-3
4-(5-chloro-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; nitric acid / water / 5 h / 0 - 20 °C

2: potassium hydroxide / water / 3 h / Reflux

3: iron; ammonium chloride / water; ethanol / 10 h / 20 °C

4: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 80 °C

5: potassium tert-butylate / N,N-dimethyl-formamide / 15 h / 120 °C

With 1-hydroxy-7-aza-benzotriazole; sulfuric acid; potassium tert-butylate; nitric acid; iron; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide;