5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester

Base Information

Chemical Name:5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester
CAS No.:75020-41-6
Molecular Formula:C₁₃H₁₅N₃O₄
Molecular Weight:277.28
Hs Code.:

Synonyms:5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester

Suppliers and Price of 5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 4 raw suppliers

Chemical Property of 5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester

Chemical Property:

Purity/Quality:: 98% ,99% , ^*data from raw suppliers

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Technology Process of 5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester

There total 4 articles about 5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 70978-37-9
1-(azidomethyl)-4-methoxybenzene

: 105-53-3
diethyl malonate

: 75020-41-6
5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 40 ℃; for 72h;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 75020-41-6
5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 15 h / 23 °C

2: sodium / ethanol / 24 h / Reflux

With sodium azide; sodium; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 75020-41-6
5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / diethyl ether / 5 h / 20 °C / Schlenk technique; Inert atmosphere

2.1: sodium azide / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere; Schlenk technique

3.1: sodium ethanolate / ethanol / 0.5 h / Inert atmosphere; Schlenk technique

3.2: 18 h / Inert atmosphere; Schlenk technique; Reflux

With thionyl chloride; sodium azide; sodium ethanolate; In diethyl ether; ethanol; N,N-dimethyl-formamide;