5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester

Base Information

• Chemical Name: 5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester
• CAS No.: 75020-41-6
• Molecular Formula: C₁₃H₁₅N₃O₄
• Molecular Weight: 277.28
• Mol file: 75020-41-6.mol

Synonyms:5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester

Chemical Property of 5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester

There total 4 articles about 5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-(azidomethyl)-4-methoxybenzene (70978-37-9) + diethyl malonate (105-53-3) → 5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester (75020-41-6)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 40 ℃; for 72h;

Reference yield:

p-methoxybenzyl chloride (824-94-2) → 5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester (75020-41-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 15 h / 23 °C

2: sodium / ethanol / 24 h / Reflux

With sodium azide; sodium; In ethanol; N,N-dimethyl-formamide;

Reference yield:

4-Methoxybenzyl alcohol (105-13-5) → 5-Hydroxy-1-<(4-methoxyphenyl)methyl>-1H-1,2,3-triazole-4-carboxylic Acid Ethyl Ester (75020-41-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride / diethyl ether / 5 h / 20 °C / Schlenk technique; Inert atmosphere

2.1: sodium azide / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere; Schlenk technique

3.1: sodium ethanolate / ethanol / 0.5 h / Inert atmosphere; Schlenk technique

3.2: 18 h / Inert atmosphere; Schlenk technique; Reflux

With thionyl chloride; sodium azide; sodium ethanolate; In diethyl ether; ethanol; N,N-dimethyl-formamide;

upstream raw materials:

1-(azidomethyl)-4-methoxybenzene

diethyl malonate

p-methoxybenzyl chloride

4-Methoxybenzyl alcohol

Downstream raw materials:

ethyl 1-[(4-methoxyphenyl)methyl]-5-[3-(trifluoromethoxy)phenoxy]-1H-1,2,3-triazole-4-carboxylate