⁽⁵⁾-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(1H-imidazol-2-yl)heptanoate

Base Information

Chemical Name:⁽⁵⁾-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(1H-imidazol-2-yl)heptanoate
CAS No.:1609191-04-9
Molecular Formula:C₂₂H₃₁N₃O₄
Molecular Weight:401.506
Hs Code.:

<sup>(5)</sup>-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(1H-imidazol-2-yl)heptanoate

Synonyms:⁽⁵⁾-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(1H-imidazol-2-yl)heptanoate

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Chemical Property of ⁽⁵⁾-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(1H-imidazol-2-yl)heptanoate

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Technology Process of ⁽⁵⁾-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(1H-imidazol-2-yl)heptanoate

There total 3 articles about ⁽⁵⁾-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(1H-imidazol-2-yl)heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1609191-03-8
(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-8-oxooctanoate

: 4405-13-4
glyoxal trimer dihydrate

: 1609191-04-9
⁽⁵⁾-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(1H-imidazol-2-yl)heptanoate

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 72h; Sealed tube;
DOI:10.1021/acsmedchemlett.5b00468

Reference yield:

: 49645-27-4
(S)-2-(((benzyloxy)carbonyl)amino)-8-(tert-butoxy)-8-oxooctanoic acid

: 1609191-04-9
⁽⁵⁾-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(1H-imidazol-2-yl)heptanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 16 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -20 °C

3.1: ammonia / methanol / 72 h / 20 °C / Sealed tube

With lithium aluminium tetrahydride; ammonia; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1609191-02-7
(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-8-(methoxy(methyl)amino)-8-oxooctanoate

: 1609191-04-9
⁽⁵⁾-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(1H-imidazol-2-yl)heptanoate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -20 °C

2: ammonia / methanol / 72 h / 20 °C / Sealed tube

With lithium aluminium tetrahydride; ammonia; In tetrahydrofuran; methanol;
DOI:10.1021/acsmedchemlett.5b00468