C₁₂H₁₃Cl₃N₂O₄

Base Information

• Chemical Name: C₁₂H₁₃Cl₃N₂O₄
• CAS No.: 102307-06-2
• Molecular Formula: C₁₂H₁₃Cl₃N₂O₄
• Molecular Weight: 355.605
• Mol file: 102307-06-2.mol

Synonyms:C₁₂H₁₃Cl₃N₂O₄

Chemical Property of C₁₂H₁₃Cl₃N₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₃Cl₃N₂O₄

There total 1 articles about C₁₂H₁₃Cl₃N₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-butoxycarbonylhydrazine (870-46-2) + 2,4,5-Trichlorophenyl chloroformate (16947-69-6) → C12H13Cl3N2O4 (102307-06-2)

Guidance literature:

With triethylamine; In chloroform; at 23 ℃;

DOI:10.1021/jm00157a018

Reference yield: 81.0%

L-phenylalanyl-L-leucine benzyl ester (63649-15-0) + C12H13Cl3N2O4 (102307-06-2) → N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucine benzyl ester (102307-07-3)

Guidance literature:

With benzotriazol-1-ol; In N,N-dimethyl-formamide; at 23 ℃; for 15h;

DOI:10.1021/jm00157a018

Reference yield:

C12H13Cl3N2O4 (102307-06-2) → N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucine (102307-08-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / N-hydroxybenzotriazole (HOBt) / dimethylformamide / 15 h / 23 °C

2: 92 percent / H₂ / 10percent Pd/C / methanol; dimethylformamide / 4 h / 760 Torr

With hydrogen; benzotriazol-1-ol; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00157a018

upstream raw materials:

t-butoxycarbonylhydrazine

2,4,5-Trichlorophenyl chloroformate

Downstream raw materials:

N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucine benzyl ester

N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucine

N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucyl-N^G-nitroarginyl-N^G-nitroarginylisoleucine methyl ester