trans-4-Methycyclohexyl isocyanate

Base Information

• Chemical Name: trans-4-Methycyclohexyl isocyanate
• CAS No.: 32175-00-1
• Molecular Formula: C8H13NO
• Molecular Weight: 139.197
• Hs Code.: 2929109000
• Mol file: 32175-00-1.mol

Synonyms:Isocyanicacid, 4-methylcyclohexyl ester, trans- (8CI);trans-1-Isocyanato-4-methylcyclohexane;

Chemical Property of trans-4-Methycyclohexyl isocyanate

Chemical Property:

• Appearance/Colour: clear colourless liquid
• Vapor Pressure: 0.818mmHg at 25°C
• Refractive Index: 1.518
• Boiling Point: 182.2 °C at 760 mmHg
• Flash Point: 60.1 °C
• PSA: 29.43000
• Density: 1.04 g/cm³
• LogP: 1.90090

Purity/Quality:

99% ^*data from raw suppliers

trans-4-Methylcyclohexylisocyanate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of trans-4-Methycyclohexyl isocyanate

There total 2 articles about trans-4-Methycyclohexyl isocyanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C8H14FNO → (1R,4R)-1-isocyanato-4-methylcyclohexane (32175-00-1)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃; for 3h; under 760.051 Torr; Concentration;

Reference yield:

phosgene (75-44-5) + trans-4-methylcyclohexanamine (2523-55-9) → (1R,4R)-1-isocyanato-4-methylcyclohexane (32175-00-1)

Guidance literature:

DOI:10.1111/j.2042-7158.1964.tb07510.x

Reference yield: 94.5%

(1R,4R)-1-isocyanato-4-methylcyclohexane (32175-00-1) + N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide (119018-29-0) → glimepiride (93479-97-1)

Guidance literature:

In tert-butyl methyl ether; cyclohexanone; at 30 ℃; for 10h; Temperature;

upstream raw materials:

phosgene

trans-4-methylcyclohexanamine

Downstream raw materials:

C₂₅H₃₂ClN₃O₄S

C₂₅H₃₃N₃O₄S

Refernces

• 1、 HAYMAN,PETROW,STEPHENSON. "HYPOGLYCAEMIC AGENTS.". . p. 538 - 548. Retrieved 2007/10/07.