(αR)-α-[(3S)-3-(tert-ButyloxycarbonylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid

Base Information

Chemical Name:(αR)-α-[(3S)-3-(tert-ButyloxycarbonylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid
CAS No.:223526-67-8
Molecular Formula:C₂₀H₂₈FNO₅
Molecular Weight:381.444
Hs Code.:
Mol file:223526-67-8.mol

Synonyms:(2R,5S)-5-(tert-butoxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanic acid

Suppliers and Price of (αR)-α-[(3S)-3-(tert-ButyloxycarbonylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(αR)-α-[(3S)-3-(tert-Butyloxycarbonylamino)-4-methyl-2-oxopentyl]-4-fluoro-benzenepropanoicAcid
5mg
$ 165.00

Medical Isotopes, Inc.
(αR)-α-[(3S)-3-(tert-Butyloxycarbonylamino)-4-methyl-2-oxopentyl]-4-fluoro-benzenepropanoicAcid
50 mg
$ 2200.00

Total 2 raw suppliers

Chemical Property of (αR)-α-[(3S)-3-(tert-ButyloxycarbonylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid

Chemical Property:

Solubility.:Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

99% ^*data from raw suppliers

(αR)-α-[(3S)-3-(tert-Butyloxycarbonylamino)-4-methyl-2-oxopentyl]-4-fluoro-benzenepropanoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (αR)-α-[(3S)-3-(tert-ButyloxycarbonylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid can be used in the preparation of rhinovirus protease inhibitors and peptidomimetic α,β-unsaturated esters.

Technology Process of (αR)-α-[(3S)-3-(tert-ButyloxycarbonylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid

There total 33 articles about (αR)-α-[(3S)-3-(tert-ButyloxycarbonylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 862414-80-0
(2R,5S)-methyl 5-(tert-butoxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate

: 223526-67-8
(2R,5S)-5-(tert-butoxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanic acid

Guidance literature:: With lithium hydroxide; In methanol; water; at 0 ℃; for 1h;
DOI:10.1016/j.bmc.2005.05.065

Reference yield:

: 18125-46-7
(R)-4-fluorophenylalanine

: 223526-67-8
(2R,5S)-5-(tert-butoxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanic acid

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen bromide; sodium nitrite / 11 h / 0 - 20 °C

2: sulfuric acid / 2 h / 70 °C

3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 8 h / 80 °C

4: trifluoroacetic acid / dichloromethane / 4 h / 30 °C

5: palladium on activated charcoal; hydrogen / methanol / 25 °C

6: triethylamine / 2 h

7: sodium hydroxide / ethanol; water / 1 h / 20 °C

With sulfuric acid; palladium on activated charcoal; hydrogen bromide; hydrogen; potassium carbonate; triethylamine; trifluoroacetic acid; potassium iodide; sodium hydroxide; sodium nitrite; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1007/s11426-011-4478-5

Reference yield:

: (2R,4S,5S)-5-tert-Butoxycarbonylamino-2-(4-fluoro-benzyl)-4-hydroxy-6-methyl-heptanoic acid

: 223526-67-8
(2R,5S)-5-(tert-butoxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanic acid

Guidance literature:: With tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide; In dichloromethane; at 23 ℃; for 1.33h;
DOI:10.1021/jm980537b