(2R,5S)-methyl 5-(tert-butoxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate

Base Information

Chemical Name:(2R,5S)-methyl 5-(tert-butoxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate
CAS No.:862414-80-0
Molecular Formula:C₂₁H₃₀FNO₅
Molecular Weight:395.471
Hs Code.:

Synonyms:(2R,5S)-methyl 5-(tert-butoxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate

Suppliers and Price of (2R,5S)-methyl 5-(tert-butoxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2R,5S)-methyl 5-(tert-butoxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of (2R,5S)-methyl 5-(tert-butoxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate

There total 10 articles about (2R,5S)-methyl 5-(tert-butoxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 328273-02-5
(2R,5S)-methyl 5-(benzyloxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate

: 24424-99-5
di-tert-butyl dicarbonate

: 862414-80-0
(2R,5S)-methyl 5-(tert-butoxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 10h;
DOI:10.1016/j.bmc.2005.05.065

Reference yield:

: 18125-46-7
(R)-4-fluorophenylalanine

: 862414-80-0
(2R,5S)-methyl 5-(tert-butoxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen bromide; sodium nitrite / 11 h / 0 - 20 °C

2: sulfuric acid / 2 h / 70 °C

3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 8 h / 80 °C

4: trifluoroacetic acid / dichloromethane / 4 h / 30 °C

5: palladium on activated charcoal; hydrogen / methanol / 25 °C

6: triethylamine / 2 h

With sulfuric acid; palladium on activated charcoal; hydrogen bromide; hydrogen; potassium carbonate; triethylamine; trifluoroacetic acid; potassium iodide; sodium nitrite; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s11426-011-4478-5

Reference yield:

: (3R)-1-tert-butyl 4-methyl 2-((S)-2-(benzyloxycarbonylamino)-3-methylbutanoyl)-3-(4-fluorobenzyl)succinate

: 862414-80-0
(2R,5S)-methyl 5-(tert-butoxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate

Guidance literature:: Multi-step reaction with 2 steps

1: CF₃CO₂H / CH₂Cl₂ / 24 h / 20 °C

2: 83 percent / H₂ / Pd-C / methanol / 10 h / 20 °C

With hydrogen; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2005.05.065