(αR)-α-[(3S)-3-(CarboxybenzylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid

Base Information

Chemical Name:(αR)-α-[(3S)-3-(CarboxybenzylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid
CAS No.:328273-02-5
Molecular Formula:C₂₄H₂₈FNO₅
Molecular Weight:429.488
Hs Code.:
Mol file:328273-02-5.mol

Synonyms:(2R,5S)-methyl 5-(benzyloxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate

Suppliers and Price of (αR)-α-[(3S)-3-(CarboxybenzylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(αR)-α-[(3S)-3-(Carboxybenzylamino)-4-methyl-2-oxopentyl]-4-fluoro-benzenepropanoicAcid
5mg
$ 140.00

Medical Isotopes, Inc.
(αR)-α-[(3S)-3-(Carboxybenzylamino)-4-methyl-2-oxopentyl]-4-fluoro-benzenepropanoicAcid
5 mg
$ 625.00

Total 1 raw suppliers

Chemical Property of (αR)-α-[(3S)-3-(CarboxybenzylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid

Chemical Property:

Solubility.:Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:: (αR)-α-[(3S)-3-(Carboxybenzylamino)-4-methyl-2-oxopentyl]-4-fluoro-benzenepropanoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Used in the preparation of rhinovirus protease inhibitors and peptidomimetic α,β-unsaturated esters. (αR)-α-[(3S)-3-(CarboxybenzylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic acid is used in the preparation of rhinovirus protease inhibitors and peptidomimetic α,β-unsaturated esters.

Technology Process of (αR)-α-[(3S)-3-(CarboxybenzylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid

There total 9 articles about (αR)-α-[(3S)-3-(CarboxybenzylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: (3R)-1-tert-butyl 4-methyl 2-((S)-2-(benzyloxycarbonylamino)-3-methylbutanoyl)-3-(4-fluorobenzyl)succinate

: 328273-02-5
(2R,5S)-methyl 5-(benzyloxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 30 ℃; for 4h;
DOI:10.1007/s11426-011-4478-5

Reference yield:

: 18125-46-7
(R)-4-fluorophenylalanine

: 328273-02-5
(2R,5S)-methyl 5-(benzyloxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen bromide; sodium nitrite / 11 h / 0 - 20 °C

2: sulfuric acid / 2 h / 70 °C

3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 8 h / 80 °C

4: trifluoroacetic acid / dichloromethane / 4 h / 30 °C

With sulfuric acid; hydrogen bromide; potassium carbonate; trifluoroacetic acid; potassium iodide; sodium nitrite; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s11426-011-4478-5

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 328273-02-5
(2R,5S)-methyl 5-(benzyloxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 1 h / 20 °C

1.2: 65 percent / lithium diisopropylamide / tetrahydrofuran / 1 h / -78 °C

2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

2.2: tetrahydrofuran / 24 h / 0 - 20 °C

3.1: CF₃CO₂H / CH₂Cl₂ / 24 h / 20 °C

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2005.05.065