(2R)-3-(4-Fluorophenyl)-2-trifluoromethane-sulfonyloxypropionic Acid Methyl Ester

Base Information

Chemical Name:(2R)-3-(4-Fluorophenyl)-2-trifluoromethane-sulfonyloxypropionic Acid Methyl Ester
CAS No.:328273-04-7
Molecular Formula:C₁₁H₁₀F₄O₅S
Molecular Weight:330.257
Hs Code.:

Synonyms:(2R)-3-(4-Fluorophenyl)-2-trifluoromethane-sulfonyloxypropionic Acid Methyl Ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-3-(4-Fluorophenyl)-2-trifluoromethane-sulfonyloxypropionic Acid Methyl Ester

Chemical Property:

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Technology Process of (2R)-3-(4-Fluorophenyl)-2-trifluoromethane-sulfonyloxypropionic Acid Methyl Ester

There total 2 articles about (2R)-3-(4-Fluorophenyl)-2-trifluoromethane-sulfonyloxypropionic Acid Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124980-98-9
(R)-methyl 3-(4-fluorophenyl)-2-hydroxypropanoate

: 108-48-5
2,6-dimethylpyridine

: 328273-04-7
(2R)-3-(4-Fluorophenyl)-2-trifluoromethane-sulfonyloxypropionic Acid Methyl Ester

Guidance literature:: With hydrogenchloride; trifluoromethanesulfonic acid anhydride; In dichloromethane;

Reference yield:

: 124980-98-9
(R)-methyl 3-(4-fluorophenyl)-2-hydroxypropanoate

: 358-23-6
trifluoromethylsulfonic anhydride

: 328273-04-7
(2R)-3-(4-Fluorophenyl)-2-trifluoromethane-sulfonyloxypropionic Acid Methyl Ester

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 0.666667h;
DOI:10.1016/j.bmc.2005.05.065

Reference yield:

: 328273-04-7
(2R)-3-(4-Fluorophenyl)-2-trifluoromethane-sulfonyloxypropionic Acid Methyl Ester

: 328086-55-1
(2R,5S)-2-(4-Fluoro-benzyl)-6-methyl-5-[(5-methyl-isoxazole-3-carbonyl)-amino]-4-oxo-heptanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

1.2: tetrahydrofuran / 24 h / 0 - 20 °C

2.1: CF₃CO₂H / CH₂Cl₂ / 24 h / 20 °C

3.1: 83 percent / H₂ / Pd-C / methanol / 10 h / 20 °C

4.1: 90 percent / lithium hydroxide / H₂O; methanol / 1 h / 0 °C

5.1: 84 percent / Cs₂CO₃ / dimethylformamide / 5 h / 45 °C

6.1: HCl / dioxane / 2 h / 20 °C

7.1: 187 mg / 4-methylmorpholine / CH₂Cl₂ / 2 h / 25 °C

8.1: 85 percent / morpholine / Pd(PPh₃)4 / tetrahydrofuran / 3 h / 25 °C

With morpholine; 4-methyl-morpholine; hydrogenchloride; lithium hydroxide; hydrogen; sodium hydride; caesium carbonate; trifluoroacetic acid; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.05.065