methyl-3-(2-(2-(3-(2-(3-(tert-butoxycarbonylamino)propoxy) benzyl)ureido )thiazole-4-carboxamido )acetamido )-3-phenylpropanoate

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Chemical Name:methyl-3-(2-(2-(3-(2-(3-(tert-butoxycarbonylamino)propoxy) benzyl)ureido )thiazole-4-carboxamido )acetamido )-3-phenylpropanoate
CAS No.:1448992-70-8
Molecular Formula:C₃₂H₄₀N₆O₈S
Molecular Weight:668.771
Hs Code.:

Synonyms:methyl-3-(2-(2-(3-(2-(3-(tert-butoxycarbonylamino)propoxy) benzyl)ureido )thiazole-4-carboxamido )acetamido )-3-phenylpropanoate

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Chemical Property of methyl-3-(2-(2-(3-(2-(3-(tert-butoxycarbonylamino)propoxy) benzyl)ureido )thiazole-4-carboxamido )acetamido )-3-phenylpropanoate

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Technology Process of methyl-3-(2-(2-(3-(2-(3-(tert-butoxycarbonylamino)propoxy) benzyl)ureido )thiazole-4-carboxamido )acetamido )-3-phenylpropanoate

There total 11 articles about methyl-3-(2-(2-(3-(2-(3-(tert-butoxycarbonylamino)propoxy) benzyl)ureido )thiazole-4-carboxamido )acetamido )-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.6%

: 1448992-69-5
[(2-{3-[2-(3-tert-butoxycarbonylamino-propoxy)-benzyl ]-ureido}-thiazole-4-carbonyl)-amino ]-acetic acid

: 22838-46-6,88831-43-0,127022-80-4,144494-72-4
methyl 3-amino-3-phenylpropionate hydrochloride

: 1448992-70-8
methyl-3-(2-(2-(3-(2-(3-(tert-butoxycarbonylamino)propoxy) benzyl)ureido )thiazole-4-carboxamido )acetamido )-3-phenylpropanoate

Guidance literature:: [(2-{3-[2-(3-tert-butoxycarbonylamino-propoxy)-benzyl ]-ureido}-thiazole-4-carbonyl)-amino ]-acetic acid; With di-isopropyl azodicarboxylate; 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium-3-oxide hexafluorophosphate; at 20 ℃; for 0.333333h;

methyl 3-amino-3-phenylpropionate hydrochloride; for 16h;

Reference yield:

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 1448992-70-8
methyl-3-(2-(2-(3-(2-(3-(tert-butoxycarbonylamino)propoxy) benzyl)ureido )thiazole-4-carboxamido )acetamido )-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: hydrazine hydrate / 20 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 - 80 °C

5.1: lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 20 °C

6.1: di-isopropyl azodicarboxylate; 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium-3-oxide hexafluorophosphate / 0.33 h / 20 °C

6.2: 16 h

With lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium-3-oxide hexafluorophosphate; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 63452-53-9
N-acetyl-2-methoxybenzylamine

: 1448992-70-8
methyl-3-(2-(2-(3-(2-(3-(tert-butoxycarbonylamino)propoxy) benzyl)ureido )thiazole-4-carboxamido )acetamido )-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: boron tribromide / dichloromethane / 2 h / -10 - 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: hydrazine hydrate / 20 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 - 80 °C

6.1: lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 20 °C

7.1: di-isopropyl azodicarboxylate; 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium-3-oxide hexafluorophosphate / 0.33 h / 20 °C

7.2: 16 h

With lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium-3-oxide hexafluorophosphate; boron tribromide; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;