[(2-{3-[2-(3-tert-butoxycarbonylamino-propoxy)-benzyl ]-ureido}-thiazole-4-carbonyl)-amino ]-acetic acid

Base Information

Chemical Name:[(2-{3-[2-(3-tert-butoxycarbonylamino-propoxy)-benzyl ]-ureido}-thiazole-4-carbonyl)-amino ]-acetic acid
CAS No.:1448992-69-5
Molecular Formula:C₂₂H₂₉N₅O₇S
Molecular Weight:507.568
Hs Code.:

Synonyms:[(2-{3-[2-(3-tert-butoxycarbonylamino-propoxy)-benzyl ]-ureido}-thiazole-4-carbonyl)-amino ]-acetic acid

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Chemical Property of [(2-{3-[2-(3-tert-butoxycarbonylamino-propoxy)-benzyl ]-ureido}-thiazole-4-carbonyl)-amino ]-acetic acid

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Technology Process of [(2-{3-[2-(3-tert-butoxycarbonylamino-propoxy)-benzyl ]-ureido}-thiazole-4-carbonyl)-amino ]-acetic acid

There total 10 articles about [(2-{3-[2-(3-tert-butoxycarbonylamino-propoxy)-benzyl ]-ureido}-thiazole-4-carbonyl)-amino ]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.9%

: 1448992-67-3
[ (2-{3-[2-(3-tert-butoxycarbonylamino-propoxy)-benzyl]-ureido}thiazole-4-carbonyl)-amino]-acetic acid methyl ester

: 1448992-69-5
[(2-{3-[2-(3-tert-butoxycarbonylamino-propoxy)-benzyl ]-ureido}-thiazole-4-carbonyl)-amino ]-acetic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 1448992-69-5
[(2-{3-[2-(3-tert-butoxycarbonylamino-propoxy)-benzyl ]-ureido}-thiazole-4-carbonyl)-amino ]-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2: hydrazine hydrate / 20 h / Reflux

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 - 80 °C

5: lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 20 °C

With lithium hydroxide monohydrate; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 63452-53-9
N-acetyl-2-methoxybenzylamine

: 1448992-69-5
[(2-{3-[2-(3-tert-butoxycarbonylamino-propoxy)-benzyl ]-ureido}-thiazole-4-carbonyl)-amino ]-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: boron tribromide / dichloromethane / 2 h / -10 - 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3: hydrazine hydrate / 20 h / Reflux

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 - 80 °C

6: lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 20 °C

With lithium hydroxide monohydrate; boron tribromide; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;