1-[5-chloro-4-(3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy)-3-methoxyphenyl]-3-(tert-butyldimethylsiloxy)propane

Base Information

• Chemical Name: 1-[5-chloro-4-(3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy)-3-methoxyphenyl]-3-(tert-butyldimethylsiloxy)propane
• CAS No.: 704913-02-0
• Molecular Formula: C₃₃H₅₄Cl₂O₆Si₂
• Molecular Weight: 673.865

Synonyms:1-[5-chloro-4-(3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy)-3-methoxyphenyl]-3-(tert-butyldimethylsiloxy)propane

Chemical Property of 1-[5-chloro-4-(3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy)-3-methoxyphenyl]-3-(tert-butyldimethylsiloxy)propane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[5-chloro-4-(3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy)-3-methoxyphenyl]-3-(tert-butyldimethylsiloxy)propane

There total 9 articles about 1-[5-chloro-4-(3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy)-3-methoxyphenyl]-3-(tert-butyldimethylsiloxy)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl iodide (74-88-4) + 3-chloro-2-[3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-5-[3-(tert-butyldimethylsiloxy)propyl]phenol (704912-92-5) → 1-[5-chloro-4-(3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy)-3-methoxyphenyl]-3-(tert-butyldimethylsiloxy)propane (704913-02-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2004.02.154 DOI:10.1016/j.bmc.2005.11.055

Reference yield:

3-(4'-hydroxyphenyl)-1-propyl acetate (80373-18-8) → 1-[5-chloro-4-(3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy)-3-methoxyphenyl]-3-(tert-butyldimethylsiloxy)propane (704913-02-0)

Guidance literature:

Multi-step reaction with 9 steps

1.1: 64 percent / SO₂Cl₂ / 5 h / 0 °C

2.1: 100 percent / pyridine*HBr₃; pyridine / CHCl₃ / 3 h / 0 °C

3.1: 50 percent / LiClO₄ / Electrochemical reaction

4.1: 70 percent / Zn; AcOH / tetrahydrofuran / 0 °C

5.1: 100 percent / DIPEA / CH₂Cl₂

6.1: 100 percent / K₂CO₃; MeOH / 20 °C

7.1: 100 percent / imidazole / dimethylformamide / 6 h

8.1: n-BuLi / tetrahydrofuran; hexane / 0.05 h / -78 °C

8.2: B(OMe)3 / tetrahydrofuran; hexane / 2 h

8.3: 64 percent / H₂O₂; NaOH / tetrahydrofuran; hexane; H₂O / 0 °C

9.1: 100 percent / K₂CO₃ / dimethylformamide

With pyridine; 1H-imidazole; methanol; n-butyllithium; sulfuryl dichloride; pyridinium perbromide hydrobromide; lithium perchlorate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.11.055

Reference yield:

3-(5-bromo-3-chloro-4-hydroxyphenyl)propyl acetate (704912-87-8) → 1-[5-chloro-4-(3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy)-3-methoxyphenyl]-3-(tert-butyldimethylsiloxy)propane (704913-02-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 50 percent / LiClO₄ / Electrochemical reaction

2.1: 70 percent / Zn; AcOH / tetrahydrofuran / 0 °C

3.1: 100 percent / DIPEA / CH₂Cl₂

4.1: 100 percent / K₂CO₃; MeOH / 20 °C

5.1: 100 percent / imidazole / dimethylformamide / 6 h

6.1: n-BuLi / tetrahydrofuran; hexane / 0.05 h / -78 °C

6.2: B(OMe)3 / tetrahydrofuran; hexane / 2 h

6.3: 64 percent / H₂O₂; NaOH / tetrahydrofuran; hexane; H₂O / 0 °C

7.1: 100 percent / K₂CO₃ / dimethylformamide

With 1H-imidazole; methanol; n-butyllithium; lithium perchlorate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.11.055

upstream raw materials:

methyl iodide

3-chloro-2-[3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-5-[3-(tert-butyldimethylsiloxy)propyl]phenol

acetic acid 3-(3-chloro-4-hydroxy-phenyl)-propyl ester

3-(4'-hydroxyphenyl)-1-propyl acetate

Downstream raw materials:

1-[4-(2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy)-3-methoxyphenyl]-3-(tert-butyldimethylsiloxy)propane

3-[4-(5-(2-carboxyethyl)-2-(methoxymethoxy)phenoxy)-3-methoxyphenyl]propanoic acid

3-[4-[5-(2-carboxyethyl)-3-chloro-2-(methoxymethoxy)phenoxy]-5-chloro-3-methoxyphenyl]propanoic acid

N-methoxy-3-[3-chloro-5-methoxy-4-[3-chloro-2-(methoxymethoxy)-5-(2-(N-methoxy-N-methylcarbamoyl)ethyl)phenoxy]phenyl]-N-methylpropanamide

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