(+)-(1,2-syn)-3-(tert-butyldimethylsiloxy)-1-methoxy-1-(4-methoxyphenyl)-2-methylpropane

Base Information

Chemical Name:(+)-(1,2-syn)-3-(tert-butyldimethylsiloxy)-1-methoxy-1-(4-methoxyphenyl)-2-methylpropane
CAS No.:159108-92-6
Molecular Formula:C₁₈H₃₂O₃Si
Molecular Weight:324.536
Hs Code.:

Synonyms:(+)-(1,2-syn)-3-(tert-butyldimethylsiloxy)-1-methoxy-1-(4-methoxyphenyl)-2-methylpropane

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Chemical Property of (+)-(1,2-syn)-3-(tert-butyldimethylsiloxy)-1-methoxy-1-(4-methoxyphenyl)-2-methylpropane

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Technology Process of (+)-(1,2-syn)-3-(tert-butyldimethylsiloxy)-1-methoxy-1-(4-methoxyphenyl)-2-methylpropane

There total 10 articles about (+)-(1,2-syn)-3-(tert-butyldimethylsiloxy)-1-methoxy-1-(4-methoxyphenyl)-2-methylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 159108-91-5
(+)-(1,2-syn)-3-(tert-butyldimethylsiloxy)-1-(4-methoxyphenyl)-2-methylpropan-1-ol

: 74-88-4
methyl iodide

: 159108-92-6
(+)-(1,2-syn)-3-(tert-butyldimethylsiloxy)-1-methoxy-1-(4-methoxyphenyl)-2-methylpropane

Guidance literature:: With potassium hydride; In tetrahydrofuran;
DOI:10.1016/0957-4166(94)80158-4

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 159108-92-6
(+)-(1,2-syn)-3-(tert-butyldimethylsiloxy)-1-methoxy-1-(4-methoxyphenyl)-2-methylpropane

Guidance literature:: Multi-step reaction with 8 steps

1: 42 percent / Zn dust / benzene / 1 h / Heating

2: 95 percent / Jones' reagent / acetone / 1 h / 0 °C

3: 92 percent / Zn(BH₄)2 / diethyl ether; CH₂Cl₂ / 1 h / -20 °C

4: 97 percent / pyridine / 4 h / Ambient temperature

5: 8 h / 33 °C / lipase 'Amano A'; phosphate buffer pH 7.25

6: 94 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

7: 97 percent / imidazole / dimethylformamide / 0.33 h / 0 °C

8: 99 percent / KH / tetrahydrofuran / 0.17 h / Ambient temperature

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; jones' reagent; zinc(II) tetrahydroborate; potassium hydride; zinc; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone; benzene;

Reference yield:

: 17226-85-6,17226-86-7,34880-65-4,119068-85-8,136521-24-9,136521-25-0,136734-11-7
α,β-syn-methyl 3-hydroxy-2-methyl-3-(p-methoxyphenyl)propionate

: 159108-92-6
(+)-(1,2-syn)-3-(tert-butyldimethylsiloxy)-1-methoxy-1-(4-methoxyphenyl)-2-methylpropane

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / pyridine / 4 h / Ambient temperature

2: 8 h / 33 °C / lipase 'Amano A'; phosphate buffer pH 7.25

3: 94 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

4: 97 percent / imidazole / dimethylformamide / 0.33 h / 0 °C

5: 99 percent / KH / tetrahydrofuran / 0.17 h / Ambient temperature

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; potassium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;