Technology Process of (E)-2-(4-methoxylstyryl)-3,5,6-trimethylpyrazine
There total 6 articles about (E)-2-(4-methoxylstyryl)-3,5,6-trimethylpyrazine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: thionyl chloride / dichloromethane / 2.5 h / 0 °C
1.2: 0.08 h
2.1: Reflux
3.1: sodium hydride / tetrahydrofuran / 0.67 h / -5 °C
3.2: 12 h / -5 - 20 °C
With
thionyl chloride; sodium hydride;
In
tetrahydrofuran; dichloromethane;
3.1: Horner-Wadsworth-Emmons reaction / 3.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1111/j.1747-0285.2012.01332.x
- Guidance literature:
-
C12H21N2O3P;
With
sodium hydride;
In
tetrahydrofuran;
at -5 ℃;
for 0.666667h;
4-methoxy-benzaldehyde;
In
tetrahydrofuran;
at -5 - 20 ℃;
for 12h;
DOI:10.1111/j.1747-0285.2012.01332.x
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dihydrogen peroxide; acetic acid / 95 °C
2.1: 2 h / Reflux
3.1: sodium hydroxide
4.1: thionyl chloride / dichloromethane / 2.5 h / 0 °C
4.2: 0.08 h
5.1: Reflux
6.1: sodium hydride / tetrahydrofuran / 0.67 h / -5 °C
6.2: 12 h / -5 - 20 °C
With
thionyl chloride; dihydrogen peroxide; sodium hydride; acetic acid; sodium hydroxide;
In
tetrahydrofuran; dichloromethane;
6.1: Horner-Wadsworth-Emmons reaction / 6.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1111/j.1747-0285.2012.01332.x
