ethyl 4-(benzyloxy)-3-methyl-2-{ [3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl} quinoline-6-carboxylate

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Chemical Name:ethyl 4-(benzyloxy)-3-methyl-2-{ [3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl} quinoline-6-carboxylate
CAS No.:1135032-11-9
Molecular Formula:C₃₃H₃₅NO₆
Molecular Weight:541.644
Hs Code.:

Synonyms:ethyl 4-(benzyloxy)-3-methyl-2-{ [3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl} quinoline-6-carboxylate

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Chemical Property of ethyl 4-(benzyloxy)-3-methyl-2-{ [3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl} quinoline-6-carboxylate

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Technology Process of ethyl 4-(benzyloxy)-3-methyl-2-{ [3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl} quinoline-6-carboxylate

There total 9 articles about ethyl 4-(benzyloxy)-3-methyl-2-{ [3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl} quinoline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 64-17-5
ethanol

: 201230-82-2
carbon monoxide

: 1135036-35-9
4-(benzyloxy)-6-bromo-3-methyl-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinoline

: 1135032-11-9
ethyl 4-(benzyloxy)-3-methyl-2-{ [3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl} quinoline-6-carboxylate

Guidance literature:: With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine; In dimethyl sulfoxide; at 80 ℃;
DOI:10.1016/j.bmcl.2011.09.015

Reference yield:

: 1135030-91-9
[4-(benzyloxy)-6-bromo-3-methylquinolin-2-yl]methanol

: 1135032-11-9
ethyl 4-(benzyloxy)-3-methyl-2-{ [3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl} quinoline-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; thionyl chloride / tetrahydrofuran

2: potassium carbonate / N,N-dimethyl-formamide / 80 °C

3: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / dimethyl sulfoxide / 80 °C

With pyridine; thionyl chloride; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; potassium carbonate; triethylamine; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.09.015

Reference yield:

: 1135033-53-2
C₁₈H₁₅BrClNO

: 1135032-11-9
ethyl 4-(benzyloxy)-3-methyl-2-{ [3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl} quinoline-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

2: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / dimethyl sulfoxide / 80 °C

With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; potassium carbonate; triethylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.09.015