4-(benzylidene-amino)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-(benzylidene-amino)-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 1044183-50-7
• Molecular Formula: C₁₇H₂₄N₂O₂
• Molecular Weight: 288.39
• Mol file: 1044183-50-7.mol

Synonyms:4-(benzylidene-amino)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-(benzylidene-amino)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-(benzylidene-amino)-piperidine-1-carboxylic acid tert-butyl ester

There total 4 articles about 4-(benzylidene-amino)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-phenylmethylidenepiperidinyl-4-amine (1029643-92-2) + di-tert-butyl dicarbonate (24424-99-5) → 4-(benzylidene-amino)-piperidine-1-carboxylic acid tert-butyl ester (1044183-50-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1021/jo062301i

Reference yield:

4-aminopiperidine (13035-19-3) → 4-(benzylidene-amino)-piperidine-1-carboxylic acid tert-butyl ester (1044183-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 4 h / Heating

2: toluene / 12 h / 25 °C

In toluene;

DOI:10.1016/j.bmcl.2006.07.009

Reference yield:

benzaldehyde (100-52-7) → 4-(benzylidene-amino)-piperidine-1-carboxylic acid tert-butyl ester (1044183-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂SO₄ / CH₂Cl₂ / 24 h / 20 °C

2: Et₃N / CH₂Cl₂ / 48 h / 20 °C

With sodium sulfate; triethylamine; In dichloromethane;

DOI:10.1021/jo062301i

upstream raw materials:

N-phenylmethylidenepiperidinyl-4-amine

di-tert-butyl dicarbonate

4-aminopiperidine

benzaldehyde

Downstream raw materials:

3-chloro-N-piperidin-4-yl-N-(3-pyridin-4-ylbenzyl)benzo[b]thiophene-2-carboxamide

tert-butyl 4-((3-bromophenyl)methyl)aminopiperidine carboxylate

C₁₉H₂₉N₃O₃

tert-butyl 4-((4-cyanobenzyl)amino)piperidine-1-carboxylate