6-Chloro-2-(4-fluorophenyl)chromen-4-one

Base Information

Chemical Name:6-Chloro-2-(4-fluorophenyl)chromen-4-one
CAS No.:213894-75-8
Molecular Formula:C₁₅H₈ClFO₂
Molecular Weight:274.679
Hs Code.:
DSSTox Substance ID:DTXSID401234640
Nikkaji Number:J1.564.743D
ChEMBL ID:CHEMBL54512

Synonyms:6-chloro-2-(4-fluorophenyl)-4H-chromen-4-one;213894-75-8;6-chloro-2-(4-fluorophenyl)chromen-4-one;Oprea1_173251;CHEMBL54512;DTXSID401234640;STK788038;AKOS002181849;MB02375;NCGC00339314-01;VU0510081-1;AB01331926-02;2-(4-Fluorophenyl)-6-chloro-4H-1-benzopyran-4-one;6-Chloro-2-(4-fluorophenyl)-4H-1-benzopyran-4-one;F3139-0637

Suppliers and Price of 6-Chloro-2-(4-fluorophenyl)chromen-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-Chloro-2-(4-fluorophenyl)chromen-4-one

Chemical Property:

XLogP3:4.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:274.0196853
Heavy Atom Count:19
Complexity:388

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=CC(=C3)Cl)F

Technology Process of 6-Chloro-2-(4-fluorophenyl)chromen-4-one

There total 5 articles about 6-Chloro-2-(4-fluorophenyl)chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 766-98-3
1-ethynyl-4-fluorobenzene

: 635-93-8
5-chlorosalicyclaldehyde

: 213894-75-8
6-Chloro-4'-fluoroflavone

Guidance literature:: With piperidine; iron(III) chloride; In toluene; for 8h; Reflux;
DOI:10.1016/j.tetlet.2011.08.078

Reference yield: 72.0%

: 908563-71-3
(E)-1-(5-chloro-2-hydroxyphenyl)-3-(4-fluorophenyl)prop-2-en-1-one

: 213894-75-8
6-Chloro-4'-fluoroflavone

Guidance literature:: With tert.-butylhydroperoxide; sodium tetrachloropalladate(II) trihydrate; sodium acetate; In water; acetic acid; tert-butyl alcohol; at 70 ℃; for 2.5h;
DOI:10.1016/j.tetlet.2009.12.107

Reference yield:

: 766-98-3
1-ethynyl-4-fluorobenzene

: 201230-82-2
carbon monoxide

: 71643-66-8
4-chloro-2-iodo phenol

: 213894-75-8
6-Chloro-4'-fluoroflavone

: C₁₅H₈ClFO₂

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine; In tetrahydrofuran; at 50 ℃; for 24h; under 2585.81 Torr; Overall yield = 77 %; regioselective reaction;
DOI:10.1016/j.mcat.2018.03.021