2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)ethylphosphonic acid

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Chemical Name:2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)ethylphosphonic acid
CAS No.:1258595-23-1
Molecular Formula:C₂₄H₂₆N₃O₄P
Molecular Weight:451.462
Hs Code.:

Synonyms:2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)ethylphosphonic acid

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Chemical Property of 2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)ethylphosphonic acid

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Technology Process of 2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)ethylphosphonic acid

There total 12 articles about 2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)ethylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1268526-98-2
diethyl 2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)-ethylphosphonate

: 1258595-23-1
2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)ethylphosphonic acid

Guidance literature:: diethyl 2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)-ethylphosphonate; With trimethylsilyl bromide; In dichloromethane; at 0 - 20 ℃; for 2h;

With water; In dimethyl sulfoxide; pH=9;
DOI:10.1021/acs.jmedchem.6b00489

Reference yield:

: 85331-33-5
2-Cyano-3,5-dichloropyridine

: 1258595-23-1
2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)ethylphosphonic acid

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

2: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / butan-1-ol; water / 100 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / dichloromethane; ethanol / 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

5: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2.5 h / 20 °C

6: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

7: hydrogen / palladium 10% on activated carbon / dichloromethane; ethanol / 20 °C

8: trimethylsilyl bromide / dichloromethane / 2 h / 0 - 20 °C

With potassium phosphate; trimethylsilyl bromide; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1186635-72-2
5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f]-[1,7]naphthyridine-8-carbaldehyde

: 1258595-23-1
2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)ethylphosphonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / dichloromethane; ethanol / 20 °C

3: trimethylsilyl bromide / dichloromethane / 2 h / 0 - 20 °C

With trimethylsilyl bromide; hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;