diethyl 2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)-ethylphosphonate

Base Information

Chemical Name:diethyl 2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)-ethylphosphonate
CAS No.:1268526-98-2
Molecular Formula:C₂₈H₃₄N₃O₄P
Molecular Weight:507.569
Hs Code.:

Synonyms:diethyl 2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)-ethylphosphonate

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Chemical Property of diethyl 2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)-ethylphosphonate

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Technology Process of diethyl 2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)-ethylphosphonate

There total 11 articles about diethyl 2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)-ethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1268526-97-1
diethyl (E)-2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)vinylphosphonate

: 1268526-98-2
diethyl 2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)-ethylphosphonate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In 1,2-dimethoxyethane; dichloromethane; at 20 ℃;
DOI:10.1021/acs.jmedchem.6b00489

Reference yield:

: 85331-33-5
2-Cyano-3,5-dichloropyridine

: 1268526-98-2
diethyl 2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)-ethylphosphonate

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

2: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / butan-1-ol; water / 100 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / dichloromethane; ethanol / 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

5: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2.5 h / 20 °C

6: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

7: hydrogen / palladium 10% on activated carbon / dichloromethane; ethanol / 20 °C

With potassium phosphate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1186635-72-2
5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f]-[1,7]naphthyridine-8-carbaldehyde

: 1268526-98-2
diethyl 2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)-ethylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / dichloromethane; ethanol / 20 °C

With hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;