1-(5-methoxy-2-nitro-4-prop-2-ynyloxyphenyl)ethyl bromide

Base Information

• Chemical Name: 1-(5-methoxy-2-nitro-4-prop-2-ynyloxyphenyl)ethyl bromide
• CAS No.: 1456901-32-8
• Molecular Formula: C₁₂H₁₂BrNO₄
• Molecular Weight: 314.136
• Mol file: 1456901-32-8.mol

Synonyms:1-(5-methoxy-2-nitro-4-prop-2-ynyloxyphenyl)ethyl bromide

Chemical Property of 1-(5-methoxy-2-nitro-4-prop-2-ynyloxyphenyl)ethyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(5-methoxy-2-nitro-4-prop-2-ynyloxyphenyl)ethyl bromide

There total 2 articles about 1-(5-methoxy-2-nitro-4-prop-2-ynyloxyphenyl)ethyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-ol (1255792-05-2) → 1-(5-methoxy-2-nitro-4-prop-2-ynyloxyphenyl)ethyl bromide (1456901-32-8)

Guidance literature:

With pyridine; phosphorus tribromide; In tetrahydrofuran; benzene; at 0 ℃; for 12.5h; Inert atmosphere;

DOI:10.1246/cl.130235

Reference yield:

1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one (1255792-04-1) → 1-(5-methoxy-2-nitro-4-prop-2-ynyloxyphenyl)ethyl bromide (1456901-32-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 0 °C

2: phosphorus tribromide; pyridine / tetrahydrofuran; benzene / 12.5 h / 0 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; phosphorus tribromide; In tetrahydrofuran; methanol; benzene;

DOI:10.1246/cl.130235

Reference yield: 91.0%

3,6-epoxy-1,2,3,6-tetrahydrophthalimide (6253-28-7,19878-26-3,42074-03-3) + 1-(5-methoxy-2-nitro-4-prop-2-ynyloxyphenyl)ethyl bromide (1456901-32-8) → 3-(2-methoxy-5-nitro-4-(1-(oxabicyclo[2,2,1]hept-5-enedicarboxyimide)ethyl)phenoxy)-1-propyne (1255792-08-5)

Guidance literature:

3,6-epoxy-1,2,3,6-tetrahydrophthalimide; With potassium carbonate; In N,N-dimethyl-formamide; for 0.5h;

1-(5-methoxy-2-nitro-4-prop-2-ynyloxyphenyl)ethyl bromide; at 50 ℃; for 3h; Inert atmosphere;

DOI:10.1246/cl.130235

upstream raw materials:

1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one

1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-ol

Downstream raw materials:

3-(2-methoxy-5-nitro-4-(1-(oxabicyclo[2,2,1]hept-5-enedicarboxyimide)ethyl)phenoxy)-1-propyne

2-(1-(5-methoxy-2-nitro-4-((1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione

1-(1-(5-methoxy-2-nitro-4-((1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethyl)-1H-pyrrole-2,5-dione

1-(1-(5-methoxy-2-nitro-4-((1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethyl)-3-(octylthio)pyrrolidine-2,5-dione

Refernces