(S)-methyl 3-(tert-butoxycarbonylamino)-3-methyl-2-((S)-1-phenylethylamino)butanoate

Base Information

• Chemical Name: (S)-methyl 3-(tert-butoxycarbonylamino)-3-methyl-2-((S)-1-phenylethylamino)butanoate
• CAS No.: 1093192-06-3
• Molecular Formula: C₁₉H₃₀N₂O₄
• Molecular Weight: 350.458
• Mol file: 1093192-06-3.mol

Synonyms:(S)-methyl 3-((tert-butoxycarbonyl)amino)-3-methyl-2-(((S)-1-phenylethyl)amino)butanoate

Chemical Property of (S)-methyl 3-(tert-butoxycarbonylamino)-3-methyl-2-((S)-1-phenylethylamino)butanoate

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

(S)-Methyl3-(tert-Butoxycarbonylamino)-3-methyl-2-((S)-1-phenylethylamino)butanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-methyl 3-(tert-butoxycarbonylamino)-3-methyl-2-((S)-1-phenylethylamino)butanoate

There total 4 articles about (S)-methyl 3-(tert-butoxycarbonylamino)-3-methyl-2-((S)-1-phenylethylamino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(S)-methyl 3-amino-3-methyl-2-(((S)-1-phenylethyl)amino)butanoate (1093192-05-2) + di-tert-butyl dicarbonate (24424-99-5) → (S)-methyl 3-((tert-butoxycarbonyl)amino)-3-methyl-2-(((S)-1-phenylethyl)amino)butanoate (1093192-06-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

(S)-3-methyl-3-nitro-2-(((S)-1-phenylethyl)amino)butanoic acid (1093192-03-0) → (S)-methyl 3-((tert-butoxycarbonyl)amino)-3-methyl-2-(((S)-1-phenylethyl)amino)butanoate (1093192-06-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

1.2: 13.25 h / 0 - 20 °C / Inert atmosphere

1.3: pH 7 - 8

2.1: acetic acid / tetrahydrofuran / 3.33 h / 0 °C / Molecular sieve 4?; Inert atmosphere

2.2: 18 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

(S)-methyl 3-methyl-3-nitro-2-(((S)-1-phenylethyl)amino)butanoate (1093192-04-1) → (S)-methyl 3-((tert-butoxycarbonyl)amino)-3-methyl-2-(((S)-1-phenylethyl)amino)butanoate (1093192-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / tetrahydrofuran / 3.33 h / 0 °C / Molecular sieve 4?; Inert atmosphere

1.2: 18 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

upstream raw materials:

(S)-methyl 3-amino-3-methyl-2-(((S)-1-phenylethyl)amino)butanoate

di-tert-butyl dicarbonate

(S)-1-phenyl-ethylamine

(S)-3-methyl-3-nitro-2-(((S)-1-phenylethyl)amino)butanoic acid

Downstream raw materials:

(S)-2-amino-3-(tert-butoxycarbonylamino)-3-methylbutanoic acid methyl ester

(S)-N-(3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yI)-4-(4-(2-aminophenyl)buta-1,3-diynyl)benzamide

C₂₈H₃₁N₃O₅

C₂₃H₂₃N₃O₃

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