methyl 3-isopropoxy-4-(3-isopropoxy-4-(3-benzyloxy-4-nitro-benzoylamino)-benzoylamino)-benzoate

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Chemical Name:methyl 3-isopropoxy-4-(3-isopropoxy-4-(3-benzyloxy-4-nitro-benzoylamino)-benzoylamino)-benzoate
CAS No.:1006031-14-6
Molecular Formula:C₃₅H₃₅N₃O₉
Molecular Weight:641.678
Hs Code.:

Synonyms:methyl 3-isopropoxy-4-(3-isopropoxy-4-(3-benzyloxy-4-nitro-benzoylamino)-benzoylamino)-benzoate

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Chemical Property of methyl 3-isopropoxy-4-(3-isopropoxy-4-(3-benzyloxy-4-nitro-benzoylamino)-benzoylamino)-benzoate

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Technology Process of methyl 3-isopropoxy-4-(3-isopropoxy-4-(3-benzyloxy-4-nitro-benzoylamino)-benzoylamino)-benzoate

There total 12 articles about methyl 3-isopropoxy-4-(3-isopropoxy-4-(3-benzyloxy-4-nitro-benzoylamino)-benzoylamino)-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.5%

: 1006030-92-7
methyl 3-isopropoxy-4-(3-isopropoxy-4-amino-benzoylamino)-benzoate

: 14617-29-9
4-nitro-3-phenylmethoxybenzoic acid

: 1006031-14-6
methyl 3-isopropoxy-4-(3-isopropoxy-4-(3-benzyloxy-4-nitro-benzoylamino)-benzoylamino)-benzoate

Guidance literature:: With dichlorotriphenylphosphorane; In chloroform; at 65 ℃; for 24h;
DOI:10.1039/b712606a

Reference yield: 67.0%

: methyl 4-(4-(3-(benzyloxy)-4-nitrobenzamido)-3-hydroxybenzamido)-3-hydroxybenzoate

: 75-26-3
isopropyl bromide

: 1006031-14-6
methyl 3-isopropoxy-4-(3-isopropoxy-4-(3-benzyloxy-4-nitro-benzoylamino)-benzoylamino)-benzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Inert atmosphere;
DOI:10.1039/c8nj04758h

Reference yield:

: 713-52-0
methyl 3-hydroxy-4-nitrobenzoate

: 1006031-14-6
methyl 3-isopropoxy-4-(3-isopropoxy-4-(3-benzyloxy-4-nitro-benzoylamino)-benzoylamino)-benzoate

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / Heating; Inert atmosphere

2.1: iron; ammonium chloride / ethanol; ethyl acetate / 80 °C / Inert atmosphere

3.1: dichlorotriphenylphosphorane / chloroform / 20 °C / Inert atmosphere

3.2: 0.5 h / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 80 °C / Inert atmosphere

5.1: iron; ammonium chloride / ethanol; ethyl acetate; water / 2 h / 80 °C / Inert atmosphere

6.1: dichlorotriphenylphosphorane / chloroform / 20 °C / Inert atmosphere

6.2: 0.5 h / Inert atmosphere

7.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere

8.1: cerium(III) chloride heptahydrate; sodium iodide / acetonitrile / 7 h / Inert atmosphere; Reflux

9.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium 4-methylbenzenesulfinate / chloroform; tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

10.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; cerium(III) chloride heptahydrate; iron; potassium carbonate; ammonium chloride; sodium 4-methylbenzenesulfinate; sodium iodide; dichlorotriphenylphosphorane; In tetrahydrofuran; ethanol; chloroform; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c8nj04758h