1006030-92-7

Basic information

• Product Name: methyl 3-isopropoxy-4-(3-isopropoxy-4-amino-benzoylamino)-benzoate
• Synonyms: methyl 3-isopropoxy-4-(3-isopropoxy-4-amino-benzoylamino)-benzoate
• CAS NO: 1006030-92-7
• Molecular Weight: 386.448
• Mol File: 1006030-92-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl 3-isopropoxy-4-(3-isopropoxy-4-amino-benzoylamino)-benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-isopropoxy-4-(3-isopropoxy-4-amino-benzoylamino)-benzoate(1006030-92-7)
• EPA Substance Registry System: methyl 3-isopropoxy-4-(3-isopropoxy-4-amino-benzoylamino)-benzoate(1006030-92-7)

Safety Data

• Hazardous Substances Data: 1006030-92-7(Hazardous Substances Data)

Upstream product

• 1006030-83-6 methyl 3-isopropoxy-4-(3-isopropoxy-4-nitro-benzoylamino)-benzoate 
• 681465-85-0 4-amino-3-isopropoxybenzoic acid methyl ester 
• 379261-85-5 3-(isopropyloxy)-4-nitrobenzoic acid 
• 713-52-0 methyl 3-hydroxy-4-nitrobenzoate 
• 619-14-7 3-hydroxy-4-nitro-benzoic acid 
• 159783-41-2 methyl 3-isopropyloxy-4-nitrobenzoate 

Downstream Products

• 1006031-14-6 methyl 3-isopropoxy-4-(3-isopropoxy-4-(3-benzyloxy-4-nitro-benzoylamino)-benzoylamino)-benzoate 
• 1006031-13-5 methyl 3-isopropoxy-4-(3-isopropoxy-4-(3-isopropoxy-4-nitro-benzoylamino)-benzoylamino)-benzoate 
• 1190360-18-9 methyl-3-isopropoxy-4-(3-isopropoxy-4-amino-benzoylamido)-benzoic acid 
• 1006031-03-3 methyl 3-isopropoxy-4-(3-isopropoxy-4-(3-isopropoxy-4-amino-benzoylamino)-benzoylamino)-benzoate 
• 1190360-14-5 3-isopropoxy-4-(3-isopropoxy-4-(3-isopropoxy-4-amino-benzoylamido)-benzoylamido)-benzoic acid 
• 1373319-45-9 methyl 4-(4-(5-amino-6-isopropoxypicolinamido)-3-isopropoxybenzamido)-3-isopropoxybenzoate 
• 1373319-33-5 4-(4-(5-amino-6-isopropoxypicolinamido)-3-isopropoxybenzamido)-3-isopropoxybenzoic acid 
• 1373319-41-5 methyl 3-isopropoxy-4-(3-isopropoxy-4-(6-isopropoxy-5-nitropicolinamido)benzamido)benzoate 
• 1006031-11-3 C₅₁H₅₇N₅O₁₃ 
• 1006031-09-9 C₄₁H₄₈N₄O₉ 
• 1006031-06-6 C₄₁H₄₆N₄O₁₁ 

Relevant articles and documents

The Albicidin Resistance Factor AlbD Is a Serine Endopeptidase That Hydrolyzes Unusual Oligoaromatic-Type Peptides

The para-aminobenzoic acid-containing peptide albicidin is a pathogenicity factor synthesized by Xanthomonas albilineans in infections of sugar cane. Albicidin is a nanomolar inhibitor of the bacterial DNA gyrase with a strong activity against various Gram-negative bacteria. The bacterium Pantoea dispersa expresses the hydrolase AlbD, conferring natural resistance against albicidin. We show that AlbD is a novel type of endopeptidase that catalyzes the cleavage of albicidin at a peptide backbone amide bond, thus abolishing its antimicrobial activity. Additionally, we determined the minimal cleavage motif of AlbD with substrates derived by chemical synthesis. Our results clearly identify AlbD as a unique endopeptidase that is the first member of a new subfamily of peptidases. Our findings provide the molecular basis for a natural detoxification mechanism, potentially rendering a new tool in biological chemistry approaches.

Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: Identification of potent Bcl-xL inhibitors

By conducting a structure-activity relationship study of the backbone of a series of oligoamide-foldamer-based α-helix mimetics of the Bak BH3 helix, we have identified especially potent inhibitors of Bcl-xL. The most potent compound has a Ki value of 94 nM in vitro, and single-digit micromolar IC50 values against the proliferation of several Bcl-xL-overexpressing cancer cell lines. The Royal Society of Chemistry 2012.