methyl 5-chloro-3-(ethyl (tetrahydro-2H-pyran-4-yl) amino)-2-methylbenzoate

Base Information

Chemical Name:methyl 5-chloro-3-(ethyl (tetrahydro-2H-pyran-4-yl) amino)-2-methylbenzoate
CAS No.:1403595-90-3
Molecular Formula:C₁₆H₂₂ClNO₃
Molecular Weight:311.809
Hs Code.:

Synonyms:methyl 5-chloro-3-(ethyl (tetrahydro-2H-pyran-4-yl) amino)-2-methylbenzoate

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Chemical Property of methyl 5-chloro-3-(ethyl (tetrahydro-2H-pyran-4-yl) amino)-2-methylbenzoate

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Technology Process of methyl 5-chloro-3-(ethyl (tetrahydro-2H-pyran-4-yl) amino)-2-methylbenzoate

There total 6 articles about methyl 5-chloro-3-(ethyl (tetrahydro-2H-pyran-4-yl) amino)-2-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1403595-50-5
methyl 5-chloro-2-methyl-3-((tetrahydro-2H-pyran-4-yl)amino)benzoate

: 75-03-6
ethyl iodide

: 1403595-90-3
methyl 5-chloro-3-(ethyl (tetrahydro-2H-pyran-4-yl) amino)-2-methylbenzoate

Guidance literature:: With caesium carbonate; In acetonitrile; at 80 ℃; for 18h;

Reference yield:

: 7499-06-1
5-chloro-2-methylbenzoic acid

: 1403595-90-3
methyl 5-chloro-3-(ethyl (tetrahydro-2H-pyran-4-yl) amino)-2-methylbenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 0.17 h / -10 °C

1.2: 0.5 h / -10 °C

2.1: sodium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

3.1: water; ammonium chloride; iron / ethanol / 1 h / 80 °C

4.1: acetic acid / methanol / 3 h / 20 °C

5.1: caesium carbonate / acetonitrile / 18 h / 80 °C

With sulfuric acid; water; iron; sodium carbonate; ammonium chloride; caesium carbonate; acetic acid; In methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 294190-17-3
methyl 5-chloro-2-methyl-3-nitrobenzoate

: 1403595-90-3
methyl 5-chloro-3-(ethyl (tetrahydro-2H-pyran-4-yl) amino)-2-methylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: water; ammonium chloride; iron / ethanol / 1 h / 80 °C

2: acetic acid / methanol / 3 h / 20 °C

3: caesium carbonate / acetonitrile / 18 h / 80 °C

With water; iron; ammonium chloride; caesium carbonate; acetic acid; In methanol; ethanol; acetonitrile;