(4S)-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carbonyl chloride

Base Information

• Chemical Name: (4S)-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carbonyl chloride
• CAS No.: 1232506-24-9
• Molecular Formula: C₁₂H₉ClFNO₂
• Molecular Weight: 253.66

Synonyms:(4S)-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carbonyl chloride

Chemical Property of (4S)-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carbonyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S)-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carbonyl chloride

There total 5 articles about (4S)-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

(R)-3-(4-fluorophenyl)-2-formylpentanedioic acid 1-methyl ester (1224442-80-1) → (4S)-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carbonyl chloride (1232506-24-9)

Guidance literature:

With acetic acid; methylamine; In water; at 65 ℃; enantioselective reaction;

DOI:10.1021/acs.jmedchem.5b00365

Reference yield:

(S)-4-(4-fluorophenyl)-1,4,5,6-tetrahydro-6-oxo-3-pyridinecarboxylic acid (1220248-46-3) → (4S)-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carbonyl chloride (1232506-24-9)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

4-(4-fluorophenyl)dihydropyran-2,6(3H)-dione (4926-12-9) → (4S)-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carbonyl chloride (1232506-24-9)

Guidance literature:

Multi-step reaction with 3 steps

1: C₂₉H₂₈F₆N₄OS / 2-methyltetrahydrofuran / 20 °C

2: lithium diisopropyl amide / tetrahydrofuran / -45 °C

3: acetic acid; methylamine / water / 65 °C

With C₂₉H₂₈F₆N₄OS; acetic acid; methylamine; lithium diisopropyl amide; In tetrahydrofuran; 2-methyltetrahydrofuran; water;

DOI:10.1021/acs.jmedchem.5b00365

upstream raw materials:

(S)-4-(4-fluorophenyl)-1,4,5,6-tetrahydro-6-oxo-3-pyridinecarboxylic acid

4-(4-fluorophenyl)dihydropyran-2,6(3H)-dione

(R)-3-(4-fluorophenyl)-2-formylpentanedioic acid 1-methyl ester

(S)-4-(4-fluorophenyl)-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylic acid methyl ester

Downstream raw materials:

(S)-4-(4-Fluoro-phenyl)-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid [2-methyl-5-(5-methyl-2H-pyrazol-3-yl)-phenyl]-amide

(S)-4-(4-Fluoro-phenyl)-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid (5-ethyl-quinolin-6-yl)-amide

(4S)-N-[1-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-5-methyl-indazol-6-yl]-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carboxamide

(S)-4-(4-fluoro-phenyl)-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid {1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-1H-indol-6-yl}-amide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1232506-24-9 (4S)-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carbonyl chloride

Send

Send

Metric Ton KG G Pound L ML

Send

Send