(4S)-N-[1-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-5-methyl-indazol-6-yl]-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carboxamide

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Chemical Name:(4S)-N-[1-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-5-methyl-indazol-6-yl]-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carboxamide
CAS No.:1232685-21-0
Molecular Formula:C₂₈H₃₅FN₄O₃Si
Molecular Weight:522.695
Hs Code.:

Synonyms:(4S)-N-[1-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-5-methyl-indazol-6-yl]-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carboxamide

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Chemical Property of (4S)-N-[1-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-5-methyl-indazol-6-yl]-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carboxamide

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Technology Process of (4S)-N-[1-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-5-methyl-indazol-6-yl]-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carboxamide

There total 8 articles about (4S)-N-[1-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-5-methyl-indazol-6-yl]-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.3%

: 1232506-24-9
(4S)-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carbonyl chloride

: 1232685-13-0
1-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-5-methyl-indazol-6-amine

: 1232685-21-0
(4S)-N-[1-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-5-methyl-indazol-6-yl]-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carboxamide

Guidance literature:: With pyridine; dmap; at 90 ℃; for 18h; Sealed tube;

Reference yield:

: (R)-3-(4-fluorophenyl)pentanedioic acid monomethyl ester

: 1232685-21-0
(4S)-N-[1-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-5-methyl-indazol-6-yl]-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium diisopropyl amide / tetrahydrofuran / -45 °C

2: acetic acid; methylamine / water / 65 °C

3: pyridine; dmap / 90 °C / Sealed tube

With pyridine; dmap; acetic acid; methylamine; lithium diisopropyl amide; In tetrahydrofuran; water;
DOI:10.1021/acs.jmedchem.5b00365

Reference yield:

: 1224442-80-1
(R)-3-(4-fluorophenyl)-2-formylpentanedioic acid 1-methyl ester

: 1232685-21-0
(4S)-N-[1-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-5-methyl-indazol-6-yl]-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; methylamine / water / 65 °C

2: pyridine; dmap / 90 °C / Sealed tube

With pyridine; dmap; acetic acid; methylamine; In water;
DOI:10.1021/acs.jmedchem.5b00365