methyl 2-((2-chloro-4-(dimethylcarbamoyl)phenyl)(methyl)carbamoyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxylate

Base Information

Chemical Name:methyl 2-((2-chloro-4-(dimethylcarbamoyl)phenyl)(methyl)carbamoyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxylate
CAS No.:1189816-48-5
Molecular Formula:C₂₅H₂₃ClN₂O₅S
Molecular Weight:498.987
Hs Code.:

Synonyms:methyl 2-((2-chloro-4-(dimethylcarbamoyl)phenyl)(methyl)carbamoyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxylate

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Chemical Property of methyl 2-((2-chloro-4-(dimethylcarbamoyl)phenyl)(methyl)carbamoyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxylate

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Technology Process of methyl 2-((2-chloro-4-(dimethylcarbamoyl)phenyl)(methyl)carbamoyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxylate

There total 12 articles about methyl 2-((2-chloro-4-(dimethylcarbamoyl)phenyl)(methyl)carbamoyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

8-bromo-N-(2-chloro-4-(dimethylcarbamoyl)phenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide: 1189816-46-3
8-bromo-N-(2-chloro-4-(dimethylcarbamoyl)phenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide

methyl 2-((2-chloro-4-(dimethylcarbamoyl)phenyl)(methyl)carbamoyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxylate: 1189816-48-5
methyl 2-((2-chloro-4-(dimethylcarbamoyl)phenyl)(methyl)carbamoyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxylate

Guidance literature:: With triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In N,N-dimethyl-formamide; at 70 ℃; for 48h; under 2585.81 Torr;

Reference yield:

: 157245-84-6
ethyl 4-(3-bromophenoxy)butanoate

methyl 2-((2-chloro-4-(dimethylcarbamoyl)phenyl)(methyl)carbamoyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxylate: 1189816-48-5
methyl 2-((2-chloro-4-(dimethylcarbamoyl)phenyl)(methyl)carbamoyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran / 48 h / 50 °C

2: polyphosphoric acid; celite / toluene / 5 h / 110 °C

3: N,N-dimethyl-formamide / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 50 °C

5: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 50 °C

6: thionyl chloride / 2 h / 80 °C

7: pyridine / tetrahydrofuran / 0 - 20 °C

8: caesium carbonate / N,N-dimethyl-formamide / 20 °C

9: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 48 h / 70 °C / 2585.81 Torr

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; thionyl chloride; lithium hydroxide monohydrate; water; palladium diacetate; potassium carbonate; caesium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm2007084

Reference yield:

: 1189815-76-6
methyl 8-bromo-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxylate

methyl 2-((2-chloro-4-(dimethylcarbamoyl)phenyl)(methyl)carbamoyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxylate: 1189816-48-5
methyl 2-((2-chloro-4-(dimethylcarbamoyl)phenyl)(methyl)carbamoyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 50 °C

2: thionyl chloride / 2 h / 80 °C

3: pyridine / tetrahydrofuran / 0 - 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 20 °C

5: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 48 h / 70 °C / 2585.81 Torr

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; thionyl chloride; lithium hydroxide monohydrate; water; palladium diacetate; caesium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm2007084