methyl 2-allyl-2-(p-methoxy)phenylacetate

Base Information

• Chemical Name: methyl 2-allyl-2-(p-methoxy)phenylacetate
• CAS No.: 131343-07-2
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.257
• Mol file: 131343-07-2.mol

Synonyms:methyl 2-allyl-2-(p-methoxy)phenylacetate

Chemical Property of methyl 2-allyl-2-(p-methoxy)phenylacetate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-allyl-2-(p-methoxy)phenylacetate

There total 7 articles about methyl 2-allyl-2-(p-methoxy)phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

methyl 2-(4-methoxyphenyl)prop-2-enoate (50415-68-4) + acetic acid (64-19-7,77671-22-8) → methyl 2-allyl-2-(p-methoxy)phenylacetate (131343-07-2)

Guidance literature:

With titanium(IV) dioxide; In acetonitrile; for 48h; Inert atmosphere; Irradiation; Cooling;

DOI:10.1021/jacs.0c08688

Reference yield:

methanol (67-56-1) + Estragole (140-67-0) + carbon monoxide (201230-82-2) → 4-(4-methoxyphenyl)butyric acid methyl ester (20637-08-5) + α-methyl-β-(p-methoxy-phenyl)-ethyl propionate (148149-45-5,29417-78-5) + methyl 2-allyl-2-(p-methoxy)phenylacetate (131343-07-2)

Guidance literature:

With aluminium(III) triflate; palladium diacetate; triphenylphosphine; In 5,5-dimethyl-1,3-cyclohexadiene; at 95 ℃; for 4h; under 26252.6 Torr; Overall yield = 54 %; regioselective reaction; Catalytic behavior;

DOI:10.1055/s-0035-1560912

Reference yield:

methanol (67-56-1) + carbon monoxide (201230-82-2) + E-1-(4'-methoxyphenyl)prop-1-ene (4180-23-8,25086-72-0,63589-56-0) → 4-(4-methoxyphenyl)butyric acid methyl ester (20637-08-5) + α-methyl-β-(p-methoxy-phenyl)-ethyl propionate (148149-45-5,29417-78-5) + methyl 2-allyl-2-(p-methoxy)phenylacetate (131343-07-2)

Guidance literature:

With aluminium(III) triflate; palladium diacetate; triphenylphosphine; In 5,5-dimethyl-1,3-cyclohexadiene; at 95 ℃; for 4h; under 26252.6 Torr; Overall yield = 48 %; regioselective reaction; Catalytic behavior;

DOI:10.1055/s-0035-1560912

upstream raw materials:

2-(4-methoxyphenyl)-n-butanoic acid

dimethyl sulfate

2-(4-methoxy)-phenyl-butyronitrile

methanol

Downstream raw materials:

(R)-2-(4-Methoxy-phenyl)-butyryl chloride

(S)-2-(4-Methoxy-phenyl)-butyryl chloride

(S)-2-(4-methoxyphenyl)-butanoic acid

(S)-2-(4-Methoxy-phenyl)-butyric acid methyl ester