Chemical Property of Creatine
Chemical Property:
- Appearance/Colour:White powder
- Vapor Pressure:0.00178mmHg at 25°C
- Melting Point:~295°C (dec.)
- Refractive Index:1.552
- Boiling Point:271.6 °C at 760 mmHg
- PKA:2.63(at 25℃)
- Flash Point:118.1 °C
- PSA：90.41000
- Density:1.38 g/cm3
- LogP:-0.30370
- Storage Temp.:Store at RT.
- Solubility.:Water (Slightly, Heated)
- Water Solubility.:Soluble in water.
- XLogP3:-1.2
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:3
- Exact Mass:131.069476538
- Heavy Atom Count:9
- Complexity:134
- Purity/Quality:
-
99% *data from raw suppliers
Creatine, anhydrous *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:Biological Agents -> Amino Acids and Derivatives
- Canonical SMILES:CN(CC(=O)O)C(=N)N
- Recent ClinicalTrials:Creatine Supplementation in Autism Spectrum Disorder
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Description
Creatine (N-aminoiminomethyl-N-methyl glycine) is a naturally occurring and nitrogen-containing compound comprised from amino acids that is classified within the family of guanidine phosphagens. Creatine supplementation is one of the most studied and effective ergogenic aids for athletes. The ergogenic effects of creatine supplementation are well documented, with evidence supporting its efficacy in increasing muscle strength, lean mass, and exercise performance/muscle function, particularly when combined with exercise in different populations, from athletes to a wide spectrum of patient populations.
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Uses and Mechanism of Action
Creatine supplementation in vegetarians increased total creatine, creatine, and phosphocreatine concentrations in vastus lateralis and gastrocnemius muscle, plasma, and red blood cells, often to levels greater than omnivores. Creatine supplementation increased lean tissue mass, type II fiber area, insulin-like growth factor-1, muscular strength, muscular endurance, Wingate mean power output, and brain function (memory and intelligence) in vegetarian participants. Creatine mechanisms of action involve rapid energy provision by transferring the N-phosphoryl group from phosphorylcreatine (PCr) to adenosine diphosphate (ADP), thus resynthesizing adenosine triphosphate (ATP) and spatial energy buffering, transferring energy from the mitochondria to the cytosol. Creatine is synthesized endogenously from arginine and glycine by arginine glycine amidinotransferase (AGAT) to guanidinoacetate (GAA). The GAA is then methylated by the enzyme guanidinoacetate N-methyltransferase (GAMT) with S-adenosyl methionine (SAMe) to form creatine. The kidney, pancreas, liver, and some regions in the brain contain AGAT with most GAA formed in the kidney and converted by GMAT to creatine in the liver. Endogenous creatine synthesis provides about half of the daily need for creatine. The remaining amount of creatine needed to maintain normal tissue levels of creatine is obtained in the diet primarily from red meat and fish or dietary supplements. Brain creatine content has been suggested to be affected by other factors, such as aging.
