(4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pentanoic acid methyl ester

Base Information

Chemical Name:(4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pentanoic acid methyl ester
CAS No.:122911-34-6
Molecular Formula:C₂₂H₃₁NO₅
Molecular Weight:389.492
Hs Code.:

Synonyms:(4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pentanoic acid methyl ester

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Chemical Property of (4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pentanoic acid methyl ester

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Technology Process of (4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pentanoic acid methyl ester

There total 10 articles about (4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 122911-33-5
(E)-(4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pent-2-enoic acid methyl ester

: 122911-34-6
(4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pentanoic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 0.5h; under 760 Torr; Ambient temperature;
DOI:10.1039/P19900000047

Reference yield:

: 128836-47-5
(2R,3R)-3-(2,5-Dimethoxy-3-nitro-phenyl)-3-hydroxy-2-methyl-propionic acid methyl ester

: 122911-34-6
(4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / NaH / tetrahydrofuran; dimethylformamide / 16 h / -5 °C

2: 100 percent / H₂ / 10percent Pd-C / ethanol / 2.5 h / 760 Torr

3: 91 percent / isobutyric acid / toluene / 65 h / Heating

4: 100 percent / LiAlH₄ / tetrahydrofuran / 3 h / -5 °C

5: 89 percent / SO₃*Py, Et₃N / dimethylsulfoxide; tetrahydrofuran / 0.75 h / 25 °C

6: 99.5 percent / CH₂Cl₂ / 24 h / 40 °C

7: 99 percent / H₂ / 10percent Pd-C / ethanol / 0.67 h / 760 Torr

With lithium aluminium tetrahydride; pyridine-SO₃ complex; hydrogen; sodium hydride; triethylamine; isobutyric Acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 122911-31-3
(2S,3R)-3-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-3-methoxy-2-methyl-propan-1-ol

: 122911-34-6
(4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / SO₃*Py, Et₃N / dimethylsulfoxide; tetrahydrofuran / 0.75 h / 25 °C

2: 99.5 percent / CH₂Cl₂ / 24 h / 40 °C

3: 99 percent / H₂ / 10percent Pd-C / ethanol / 0.67 h / 760 Torr

With pyridine-SO₃ complex; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;