(S)-O-Methylmandelic acid derivative of (-)-menthol

Base Information

• Chemical Name: (S)-O-Methylmandelic acid derivative of (-)-menthol
• CAS No.: 123642-96-6
• Molecular Formula: C₁₉H₂₈O₃
• Molecular Weight: 304.43
• Mol file: 123642-96-6.mol

Synonyms:(S)-O-Methylmandelic acid derivative of (-)-menthol

Chemical Property of (S)-O-Methylmandelic acid derivative of (-)-menthol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (S)-O-Methylmandelic acid derivative of (-)-menthol

There total 6 articles about (S)-O-Methylmandelic acid derivative of (-)-menthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(-)-menthol (2216-51-5) + (S)-2-methoxy-2-phenylacetic acid (26164-26-1) → (S)-O-Methylmandelic acid derivative of (-)-menthol (123642-96-6)

Guidance literature:

DOI:10.1021/jo00108a008

Reference yield:

(-)-menthol (2216-51-5) → (S)-O-Methylmandelic acid derivative of (-)-menthol (123642-96-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / p-TsOH / toluene / Heating

2: 88 percent / toluene / Heating

3: 99 percent / Et₃N / CH₂Cl₂ / Ambient temperature

4: Rh₂(OAc)4 / CH₂Cl₂ / Ambient temperature

With toluene-4-sulfonic acid; triethylamine; dirhodium tetraacetate; In dichloromethane; toluene;

DOI:10.1021/jo00119a023

Reference yield:

l-menthyl phenylglyoxylate (20229-41-8) → (S)-O-Methylmandelic acid derivative of (-)-menthol (123642-96-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / toluene / Heating

2: 99 percent / Et₃N / CH₂Cl₂ / Ambient temperature

3: Rh₂(OAc)4 / CH₂Cl₂ / Ambient temperature

With triethylamine; dirhodium tetraacetate; In dichloromethane; toluene;

DOI:10.1021/jo00119a023

upstream raw materials:

(-)-menthol

(S)-2-methoxy-2-phenylacetic acid

methanol

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-diazo-2-phenylacetate